Gastrointestinal germinal center B cell depletion and reduction in IgA + plasma cells in HIV-1 infection.

Autor: Cossarini F; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Shang J; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Krek A; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Al-Taie Z; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Hou R; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Canales-Herrerias P; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Tokuyama M; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Tankelevich M; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Tillowitz A; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Jha D; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Livanos AE; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Leyre L; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Uzzan M; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Gastroenterology Department, Hôpital Henri Mondor, APHP, Créteil, France., Martinez-Delgado G; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Taylor MD; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Sharma K; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bourgonje AR; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Cruz M; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ioannou G; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Dawson T; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., D'Souza D; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kim-Schulze S; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Akm A; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Aberg JA; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Chen BK; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kwon DS; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA., Gnjatic S; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Polydorides AD; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Cerutti A; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Translational Clinical Research Program, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.; Catalan Institute for Research and Advanced Studies (ICREA), Barcelona, Spain., Argmann C; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Vujkovic-Cvijin I; F. Widjaja IBD Institute, Division of Gastroenterology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Suarez-Fariñas M; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Petralia F; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Faith JJ; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Mehandru S; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jazyk: angličtina
Zdroj: Science immunology [Sci Immunol] 2024 Oct 25; Vol. 9 (100), pp. eado0090. Date of Electronic Publication: 2024 Oct 25.
DOI: 10.1126/sciimmunol.ado0090
Abstrakt: Gastrointestinal (GI) B cells and plasma cells (PCs) are critical to mucosal homeostasis and the host response to HIV-1 infection. Here, high-resolution mapping of human B cells and PCs sampled from the colon and ileum during both viremic and suppressed HIV-1 infection identified a reduction in germinal center (GC) B cells and follicular dendritic cells (FDCs) during HIV-1 viremia. Immunoglobulin A-positive (IgA + ) PCs are the major cellular output of intestinal GCs and were significantly reduced during viremic HIV-1 infection. PC-associated transcriptional perturbations, including type I interferon signaling, persisted in antiretroviral therapy (ART)-treated individuals, suggesting ongoing disruption of the intestinal immune milieu during ART. GI humoral immune perturbations were associated with changes in the intestinal microbiome composition and systemic inflammation. These findings highlight a key immune defect in the GI mucosa due to HIV-1 viremia.
Databáze: MEDLINE