New Discorhabdin D Analogues from Latrunculia spp. Sponges.

Autor: Orfanoudaki M; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21701-1201, United States., Dalilian M; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21701-1201, United States., Du L; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21701-1201, United States., Chau CH; Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States., Figg WD; Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States., O'Keefe BR; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21701-1201, United States.; Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick, Maryland 21702-1201, United States., Grkovic T; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21701-1201, United States.; Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick, Maryland 21702-1201, United States.
Jazyk: angličtina
Zdroj: Journal of natural products [J Nat Prod] 2024 Nov 22; Vol. 87 (11), pp. 2640-2648. Date of Electronic Publication: 2024 Oct 25.
DOI: 10.1021/acs.jnatprod.4c01036
Abstrakt: Chemical profiles of Latrunculia kaakaariki and Latrunculia brevis were investigated, resulting in the isolation of five new discorhabdin D derivatives 1 and 3 - 6 . Their planar structures were solved by combination of NMR and HR-MS, while J -based configurational analysis, computational techniques, and semisynthetic methods were used for the establishment of their absolute configurations. New natural products were tested for their growth inhibitory activity against the NCI-60 human tumor cell line panel, and two compounds 5 and 6 showed low micromolar potency.
Databáze: MEDLINE
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