| Autor: |
Zhang H; College of Tourism and Cuisine, Yangzhou University, Yangzhou 225127, China.; Engineering Research Center for Huaiyang Cuisine of Jiangsu Province, Yangzhou 225127, China.; Key Laboratory of Chinese Cuisine Intangible Cultural Heritage Technology Inheritance, Department of Culinary Science, Ministry of Culture & Tourism, Yangzhou 225127, China., Wang M; College of Tourism and Cuisine, Yangzhou University, Yangzhou 225127, China., Zhou Y; College of Food Science and Engineering, Yangzhou University, Yangzhou 225127, China., Bao S; College of Food Science and Engineering, Yangzhou University, Yangzhou 225127, China., Wang F; College of Tourism and Cuisine, Yangzhou University, Yangzhou 225127, China., Li C; College of Tourism and Cuisine, Yangzhou University, Yangzhou 225127, China.; Engineering Research Center for Huaiyang Cuisine of Jiangsu Province, Yangzhou 225127, China.; Key Laboratory of Chinese Cuisine Intangible Cultural Heritage Technology Inheritance, Department of Culinary Science, Ministry of Culture & Tourism, Yangzhou 225127, China. |
| Abstrakt: |
In this study, we investigated the protective effects of astaxanthin (AST) against oxidative stress induced by the combination of azoxymethane (AOM) and dextran sulfate sodium (DSS) in colitis-associated cancer (CAC) and TNF-α-induced human colorectal cancer cells (SW480), as well as the underlying mechanism. In vitro experiments revealed that astaxanthin reduced reactive oxygen species (ROS) generation and inhibited the expression of Phosphorylated JNK (P-JNK), Phosphorylated ERK (P-ERK), Phosphorylated p65 (P-p65), and the NF-κB downstream protein cyclooxygenase-2 (COX-2). In vivo experiments showed that astaxanthin ameliorated AOM/DSS-induced weight loss, shortened the colon length, and caused histomorphological changes. In addition, astaxanthin suppressed cellular inflammation by modulating the MAPK and NF-κB pathways and inhibiting the expression of the proinflammatory cytokines IL-6, IL-1β, and TNF-α. In conclusion, astaxanthin attenuates cellular inflammation and CAC through its antioxidant effects. |
