| Autor: |
Durna Corum D; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Hatay Mustafa Kemal, Hatay, Turkiye., Corum O; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Hatay Mustafa Kemal, Hatay, Turkiye., Uney K; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selcuk, Konya, Turkiye., Turk E; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Hatay Mustafa Kemal, Hatay, Turkiye., Sakin F; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Hatay Mustafa Kemal, Hatay, Turkiye., Giorgi M; Department of Veterinary Sciences, University of Pisa, San Piero a Grado, Italy. |
| Abstrakt: |
1. The objective of this research was to compare the pharmacokinetics and bioavailability of tolfenamic acid, analgesic, antipyretic and anti-inflammatory compound, after administration through different routes to Pekin ducks. The investigation was carried out over four time periods using a randomised cross-pharmacokinetic design.2. Tolfenamic acid was administered to ducks intravenously, intramuscularly, subcutaneously and orally at a dose of 2 mg/kg. Tolfenamic acid analysis was performed using HPLC-UV and pharmacokinetic data were conducted by non-compartmental analysis.3. The total clearance, volume of distribution at steady state and terminal elimination half-life after intravenous administration were 0.14 l/h/kg, 0.29 l/kg and 1.80 h, respectively. The peak plasma concentration and bioavailability for intramuscular, subcutaneous and oral administration were 4.59, 3.55 and 2.23 μg/ml and 93.62, 74.30 and 43.43%, respectively.4. Tolfenamic acid was absorbed rapidly, eliminated quickly and exhibited a small distribution volume in Pekin ducks. Pharmacokinetic parameters, including maximum concentration, area under the plasma concentration - time curve and bioavailability, were found to be different in ducks from other bird species. |
