| Autor: |
Hill A; Department of Biomedical Science, Noorda College of Osteopathic Medicine, Provo, UT 84606, USA., Amendolara AB; Department of Biomedical Science, Noorda College of Osteopathic Medicine, Provo, UT 84606, USA., Small C; Department of Biomedical Science, Noorda College of Osteopathic Medicine, Provo, UT 84606, USA., Guzman SC; Department of Biomedical Science, Noorda College of Osteopathic Medicine, Provo, UT 84606, USA., Pfister D; Department of Biomedical Science, Noorda College of Osteopathic Medicine, Provo, UT 84606, USA., McFarland K; Department of Biomedical Science, Noorda College of Osteopathic Medicine, Provo, UT 84606, USA., Settelmayer M; Department of Biomedical Science, Noorda College of Osteopathic Medicine, Provo, UT 84606, USA., Baker S; Department of Biomedical Science, Noorda College of Osteopathic Medicine, Provo, UT 84606, USA., Donnelly S; Department of Biomedical Science, Noorda College of Osteopathic Medicine, Provo, UT 84606, USA., Payne A; Department of Biomedical Science, Noorda College of Osteopathic Medicine, Provo, UT 84606, USA., Sant D; Department of Biomedical Science, Noorda College of Osteopathic Medicine, Provo, UT 84606, USA., Kriak J; Department of Biomedical Science, Noorda College of Osteopathic Medicine, Provo, UT 84606, USA., Bills KB; Department of Biomedical Science, Noorda College of Osteopathic Medicine, Provo, UT 84606, USA. |
| Abstrakt: |
Cortical spreading depression (CSD) is an electrophysiologic pathological state in which a wave of depolarization in the cerebral cortex is followed by the suppression of spontaneous neuronal activity. This transient spread of neuronal depolarization on the surface of the cortex is the hallmark of CSD. Numerous investigations have demonstrated that transmembrane ion transport, astrocytic ion clearing and fatigue, glucose metabolism, the presence of certain genetic markers, point mutations, and the expression of the enzyme responsible for the production of various arachidonic acid derivatives that participate in the inflammatory response, namely, cyclooxygenase (COX), all influence CSD. Here, we explore the associations between CSD occurrence in the cortex and various factors, including how CSD is related to migraines, how the glucose state affects CSD, the effect of TBI and its relationship with CSD and glucose metabolism, how different markers can be measured to determine the severity of CSD, and possible connections to oligemia, orexin, and leptin. |
