Neuropsychological Performance after Extended N-Pep-12 Dietary Supplementation in Supratentorial Ischemic Stroke.

Autor: Mureșanu D; Department of Neuroscience, Iuliu Hatieganu University of Medicine and Pharmacy, Victor Babes 8, 400347 Cluj-Napoca, Romania.; RoNeuro Institute for Neurological Research and Diagnostic, Mircea Eliade 37, 400364 Cluj-Napoca, Romania., Verișezan-Roșu O; Department of Neuroscience, Iuliu Hatieganu University of Medicine and Pharmacy, Victor Babes 8, 400347 Cluj-Napoca, Romania.; RoNeuro Institute for Neurological Research and Diagnostic, Mircea Eliade 37, 400364 Cluj-Napoca, Romania., Jemna N; RoNeuro Institute for Neurological Research and Diagnostic, Mircea Eliade 37, 400364 Cluj-Napoca, Romania., Benedek I; Department of Neuroscience, Iuliu Hatieganu University of Medicine and Pharmacy, Victor Babes 8, 400347 Cluj-Napoca, Romania.; RoNeuro Institute for Neurological Research and Diagnostic, Mircea Eliade 37, 400364 Cluj-Napoca, Romania., Rednic J; RoNeuro Institute for Neurological Research and Diagnostic, Mircea Eliade 37, 400364 Cluj-Napoca, Romania., Vlad IM; Department of Neuroscience, Iuliu Hatieganu University of Medicine and Pharmacy, Victor Babes 8, 400347 Cluj-Napoca, Romania.; RoNeuro Institute for Neurological Research and Diagnostic, Mircea Eliade 37, 400364 Cluj-Napoca, Romania., Buruiană AM; RoNeuro Institute for Neurological Research and Diagnostic, Mircea Eliade 37, 400364 Cluj-Napoca, Romania., Mureșanu I; RoNeuro Institute for Neurological Research and Diagnostic, Mircea Eliade 37, 400364 Cluj-Napoca, Romania., Chira D; Department of Neuroscience, Iuliu Hatieganu University of Medicine and Pharmacy, Victor Babes 8, 400347 Cluj-Napoca, Romania.; RoNeuro Institute for Neurological Research and Diagnostic, Mircea Eliade 37, 400364 Cluj-Napoca, Romania., Popa LL; Department of Neuroscience, Iuliu Hatieganu University of Medicine and Pharmacy, Victor Babes 8, 400347 Cluj-Napoca, Romania.; RoNeuro Institute for Neurological Research and Diagnostic, Mircea Eliade 37, 400364 Cluj-Napoca, Romania., Stan AD; Department of Neuroscience, Iuliu Hatieganu University of Medicine and Pharmacy, Victor Babes 8, 400347 Cluj-Napoca, Romania.; RoNeuro Institute for Neurological Research and Diagnostic, Mircea Eliade 37, 400364 Cluj-Napoca, Romania., Moessler H; COMAMO Lifesciences GmbH, 4893 Zell am Moos, Austria., Strilciuc Ș; RoNeuro Institute for Neurological Research and Diagnostic, Mircea Eliade 37, 400364 Cluj-Napoca, Romania.; Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Gheorghe Marinescu 32-38, 400000 Cluj-Napoca, Romania.
Jazyk: angličtina
Zdroj: Brain sciences [Brain Sci] 2024 Sep 28; Vol. 14 (10). Date of Electronic Publication: 2024 Sep 28.
DOI: 10.3390/brainsci14100986
Abstrakt: Background : Cognitive deficits following ischemic stroke significantly impair quality of life, highlighting the need for effective interventions. This study evaluates the efficacy and safety of extended N-Pep-12 dietary supplementation in enhancing cognitive recovery post-stroke. Methods : In this randomized, open-label, controlled study, 106 patients with supratentorial ischemic stroke were enrolled to receive either 90mg N-Pep-12 or no supplementation daily for 360 days and were followed-up for 360 days. Cognitive function and emotional well-being were assessed using established neuropsychological scales at baseline, 90 days, and 360 days post-stroke. Safety was monitored through adverse events and mortality rates. Results : Significant improvements were observed in the N-Pep-12 group compared to controls, particularly in the Montreal Cognitive Assessment scores at both 90 and 360 days, and in the Digit Symbol Coding scores at 360 days, suggesting enhanced cognitive recovery with extended N-Pep-12 supplementation. A linear regression for a composite outcome analysis at day 360 further confirmed the efficacy of N-Pep-12 in contributing to cognitive improvement. Safety profiles were favorable, with no significant adverse effects attributed to N-Pep-12. Conclusions : Extended dietary supplementation with N-Pep-12 appears to offer a safe and effective approach to support cognitive recovery in ischemic stroke survivors. These findings underscore the potential of the supplement as an add-on intervention for managing post-stroke cognitive impairments.
Databáze: MEDLINE
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