Comparative Immunohistochemical Analysis of Craniopharyngioma and Ameloblastoma: Insights into Odontogenic Differentiation.

Autor: Salih BA; College of Dentistry, University of Baghdad, Baghdad 10071, Iraq., Abdullah BH; College of Dentistry, University of Baghdad, Baghdad 10071, Iraq.
Jazyk: angličtina
Zdroj: Diagnostics (Basel, Switzerland) [Diagnostics (Basel)] 2024 Oct 17; Vol. 14 (20). Date of Electronic Publication: 2024 Oct 17.
DOI: 10.3390/diagnostics14202315
Abstrakt: Background and Objectives: Histopathological similarities between craniopharyngioma (CP) and ameloblastoma (AB) have long been recognized, particularly the shared features of palisading columnar epithelium and stellate reticulum-like areas. This study aimed to investigate potential odontogenic differentiation in CP akin to AB using immunohistochemical odontogenic markers.
Methods: We analyzed AMELX, ODAM, and CK19 expression in 44 cases (20 CP and 24 AB).
Results: While AMELX and ODAM showed diffuse strong positive expression in both tumors with no significant statistical differences, CK19 expression was notably higher in CP.
Conclusion: The markers AMELX and ODAM associated with odontogenic differentiation exhibited similar profiles in both tumors due to shared similar embryological origins. Notably, CK19, a biomarker of odontogenic epithelium, showed even higher expression, suggesting distinct pathways. These findings offer insights into tumor biology and may aid in diagnostic and therapeutic approaches.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje