Flower-Shaped Plasma Cells in Multiple Myeloma with Morphological Heterogeneity.

Autor: Hosoi H; Department of Hematology/Oncology, Wakayama Medical University, Wakayama 641-8509, Japan.; Department of Transfusion Medicine, Wakayama Medical University Hospital, Wakayama 641-8510, Japan., Tane M; Department of Hematology/Oncology, Wakayama Medical University, Wakayama 641-8509, Japan., Sogabe M; Department of Hematology/Oncology, Wakayama Medical University, Wakayama 641-8509, Japan., Iwamoto R; Department of Human Pathology, Wakayama Medical University, Wakayama 641-8509, Japan., Minoura N; Department of Clinical Laboratory, Wakayama Medical University Hospital, Wakayama 641-8510, Japan., Murata S; Department of Hematology/Oncology, Wakayama Medical University, Wakayama 641-8509, Japan., Mushino T; Department of Hematology/Oncology, Wakayama Medical University, Wakayama 641-8509, Japan., Nishikawa A; Department of Hematology/Oncology, Wakayama Medical University, Wakayama 641-8509, Japan.; Division of Medical Information, Wakayama Medical University Hospital, Wakayama 641-8510, Japan., Murata SI; Department of Human Pathology, Wakayama Medical University, Wakayama 641-8509, Japan., Sonoki T; Department of Hematology/Oncology, Wakayama Medical University, Wakayama 641-8509, Japan.
Jazyk: angličtina
Zdroj: Diagnostics (Basel, Switzerland) [Diagnostics (Basel)] 2024 Oct 14; Vol. 14 (20). Date of Electronic Publication: 2024 Oct 14.
DOI: 10.3390/diagnostics14202285
Abstrakt: Background: Flower-shaped nuclei in plasma cells are rare in multiple myeloma.
Case Presentation: We report on an 88-year-old male who presented with a mass lesion in the clavicular region. A biopsy of the mass revealed an increase in mature plasma cells with round nuclei. In contrast, a bone marrow examination showed increased plasma cells with flower-shaped nuclei. The patient tested negative for human T-lymphotropic virus type-1 and was diagnosed with multiple myeloma.
Conclusions: While multiple myeloma is known for intra-tumor heterogeneity, reports of morphological heterogeneity based on the site of tumor sampling are limited. In this case, the presence of plasma cells with flower-shaped nuclei enabled the identification of site-dependent morphological tumor heterogeneity.
Databáze: MEDLINE
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