| Autor: |
Liong S; Centre for Respiratory Science and Health, Royal Melbourne Institute of Technology (RMIT) University, Bundoora, VIC 3082, Australia.; School of Health and Biomedical Sciences, Royal Melbourne Institute of Technology (RMIT) University, Bundoora, VIC 3082, Australia., Liong F; Centre for Respiratory Science and Health, Royal Melbourne Institute of Technology (RMIT) University, Bundoora, VIC 3082, Australia.; School of Health and Biomedical Sciences, Royal Melbourne Institute of Technology (RMIT) University, Bundoora, VIC 3082, Australia., Mohsenipour M; School of Health and Biomedical Sciences, Royal Melbourne Institute of Technology (RMIT) University, Bundoora, VIC 3082, Australia., Hill-Yardin EL; School of Health and Biomedical Sciences, Royal Melbourne Institute of Technology (RMIT) University, Bundoora, VIC 3082, Australia., Miles MA; Centre for Respiratory Science and Health, Royal Melbourne Institute of Technology (RMIT) University, Bundoora, VIC 3082, Australia.; School of Health and Biomedical Sciences, Royal Melbourne Institute of Technology (RMIT) University, Bundoora, VIC 3082, Australia., Selemidis S; Centre for Respiratory Science and Health, Royal Melbourne Institute of Technology (RMIT) University, Bundoora, VIC 3082, Australia.; School of Health and Biomedical Sciences, Royal Melbourne Institute of Technology (RMIT) University, Bundoora, VIC 3082, Australia. |
| Abstrakt: |
Severe respiratory syncytial virus (RSV) infection during early life has been linked to gut dysbiosis, which correlates with increased disease severity and a higher risk of developing asthma later in life. However, the impact of such early-life RSV infections on intestinal immunity in adulthood remains unclear. Herein, we show that RSV infection in 3-week-old mice induced persistent differential natural killer (NK) and T cell profiles within the lungs and gastrointestinal (GI) lymphoid tissues (GALT) in adulthood. Notably, male mice exhibited more pronounced RSV-induced changes in immune cell populations in both the lungs and GALT, while female mice displayed greater resilience. Importantly, early-life RSV infection was associated with the chronic downregulation of CD69-expressing T lymphocytes, particularly T regulatory cells in Peyer's patches, which could have a significant impact on T cell functionality and immune tolerance. We propose that RSV infection in early life is a trigger for the breakdown in immune tolerance at mucosal surfaces, with potential implications for airways allergic disease, food allergies, and other GI inflammatory diseases. |
