Virus Load Kinetics in Lassa Fever Patients Treated With Ribavirin: A Retrospective Cohort Study From Southern Nigeria.
| Autor: | Ogbaini-Emovon E; Institute of Viral Haemorrhagic Fever and Emergent Pathogens, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Akpede G; Department of Pediatrics, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Okogbenin S; Department of Obstetrics and Gynaecology, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Osagiede E; Department of Community, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Tobin E; Department of Community, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Asogun D; Department of Community, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Okokhere P; Department of Medicine, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Okonofua M; Institute of Viral Haemorrhagic Fever and Emergent Pathogens, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Akpede N; Department of Community, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Akhideno P; Department of Medicine, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Erameh C; Department of Medicine, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Rafiu M; Department of Medicine, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Azubuike C; Department of Medicine, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Iraoya K; Department of Medicine, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Iruolagbe C; Department of Medicine, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Erohubie C; Department of Medicine, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Ahmed D; Department of Medicine, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Ediawe O; Institute of Viral Haemorrhagic Fever and Emergent Pathogens, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Okoguale J; Department of Obstetrics and Gynaecology, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Eifediyi R; Department of Medicine, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Odia I; Institute of Viral Haemorrhagic Fever and Emergent Pathogens, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Agbukor J; Institute of Viral Haemorrhagic Fever and Emergent Pathogens, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Adomeh D; Institute of Viral Haemorrhagic Fever and Emergent Pathogens, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Odike MAC; Department of Histopathology, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Ovienria W; Department of Ophthalmology, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Elkanem A; Institute of Viral Haemorrhagic Fever and Emergent Pathogens, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Muoebenam EB; Institute of Viral Haemorrhagic Fever and Emergent Pathogens, Irrua Specialist Teaching Hospital, Irrua, Nigeria., Ojide KC; Department of Medical Microbiology, Alex Ekwemen Federal Teaching Hospital, Abakaliki, Nigeria., Pallasch E; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Center for Infection Research (DZIF), partner site Hamburg-Borstel-Lübeck-Riems, Germany., Müller J; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany., Hinzmann J; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Center for Infection Research (DZIF), partner site Hamburg-Borstel-Lübeck-Riems, Germany., Günther S; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Center for Infection Research (DZIF), partner site Hamburg-Borstel-Lübeck-Riems, Germany., Pahlmann M; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany., Thielebein A; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany., Duraffour S; Department of Medical Microbiology, Alex Ekwemen Federal Teaching Hospital, Abakaliki, Nigeria., Oestereich L; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Center for Infection Research (DZIF), partner site Hamburg-Borstel-Lübeck-Riems, Germany., Krumkamp R; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Center for Infection Research (DZIF), partner site Hamburg-Borstel-Lübeck-Riems, Germany. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Open forum infectious diseases [Open Forum Infect Dis] 2024 Oct 15; Vol. 11 (10), pp. ofae575. Date of Electronic Publication: 2024 Oct 15 (Print Publication: 2024). |
| DOI: | 10.1093/ofid/ofae575 |
| Abstrakt: | Background: The standard of care for Lassa fever is the use of ribavirin with supportive therapy. There is little information on the course of viremia and its relationship with clinical outcomes in patients treated with ribavirin. Methods: We conducted a retrospective analysis of virologic and clinical parameters of 152 reverse transcription polymerase chain reaction-confirmed Lassa fever cases admitted and treated with ribavirin therapy. We describe the Lassa virus RNA kinetics in blood in relation to the clinical course of the patients. Results: The overall mortality was 9%. The median duration (interquartile range [IQR]) of illness before admission was 8 (5-12) days. Median (IQR) Ct values on admission ( t Conclusions: Our study demonstrates that the Ct value on admission has prognostic value and Lassa fever patients treated with ribavirin typically clear the virus within 3-4 weeks of hospitalization. This kinetics has implications for the design of clinical case management and future clinical trial protocols. Competing Interests: Potential conflicts of interest. The authors: no reported conflicts of interest. (© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|