Potential application of a combined extract of Channa striata and calcium hydroxide for inhibiting lymphocytes and interleukin-1β cells in the asymptomatic irreversible pulpitis of Wistar rats ( Rattus norvegicus ).

Autor:	Nugroho JJ; Department of Conservative Dentistry, Faculty of Dentistry, Hasanuddin University, Makassar, South Sulawesi, Indonesia.; Department of Conservative Dentistry, Hasanuddin University Dental Hospital, Makassar, South Sulawesi, Indonesia., Taha R; Department of Conservative Dentistry, Faculty of Dentistry, Hasanuddin University, Makassar, South Sulawesi, Indonesia., Trilaksana AC; Department of Conservative Dentistry, Faculty of Dentistry, Hasanuddin University, Makassar, South Sulawesi, Indonesia.; Department of Conservative Dentistry, Hasanuddin University Dental Hospital, Makassar, South Sulawesi, Indonesia., Dwiandhany WS; Department of Conservative Dentistry, Faculty of Dentistry, Hasanuddin University, Makassar, South Sulawesi, Indonesia.; Department of Conservative Dentistry, Hasanuddin University Dental Hospital, Makassar, South Sulawesi, Indonesia.
Jazyk:	angličtina
Zdroj:	Journal of conservative dentistry and endodontics [J Conserv Dent Endod] 2024 Sep; Vol. 27 (9), pp. 942-948. Date of Electronic Publication: 2024 Sep 07.
DOI:	10.4103/JCDE.JCDE_407_24
Abstrakt:	Aim: This study aimed to evaluate the effectiveness of combining Channa striata extract with calcium hydroxide (Ca(OH)2) in reducing lymphocyte counts and interleukin (IL)-1β levels in inflamed pulp teeth. Materials and Methods: A laboratory experimental setup with a posttest control group (CG) design was employed. Thirty-two rat incisor teeth were divided into four groups: a positive CG (100% Ca(OH)2), treatment 1 (25% C. striata extract + 75% Ca(OH)2), treatment 2 (50% C. striata extract + 50% Ca(OH)2), and treatment 3 (75% C. striata extract + 25% Ca(OH)2). These test materials were applied to Class 1 cavities extending to the pulp roof, with samples collected on days 1, 3, 5, and 7. Data were analyzed using analysis of variance and post hoc least significant difference tests. Results: In all the groups, the highest levels of lymphocytes and IL-1β were observed on day 3, followed by a decline on days 5 and 7. The combination of C. striata extract with Ca(OH)2 significantly reduced inflammatory markers, particularly lymphocyte and IL-1β levels. Conclusion: The extract of C. striata holds significant potential as an innovative therapeutic approach for managing inflamed dental pulp. Competing Interests: There are no conflicts of interest. (Copyright: © 2024 Journal of Conservative Dentistry and Endodontics.)
Databáze:	MEDLINE
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