[Evidence map of chikungunya treatmentsMapa de la evidencia sobre el tratamiento del chikunguña].

Autor:	de Castro AS; Universidade Federal do Piauí Programa de Mestrado em Ciências e Saúde Teresina (PI) Brasil Universidade Federal do Piauí, Programa de Mestrado em Ciências e Saúde, Teresina (PI), Brasil., Costa CHN; Centro de Inteligência em Agravos Tropicais Emergentes e Negligenciados Teresina (PI) Brasil Centro de Inteligência em Agravos Tropicais Emergentes e Negligenciados, Teresina (PI), Brasil., Costa DL; Centro de Inteligência em Agravos Tropicais Emergentes e Negligenciados Teresina (PI) Brasil Centro de Inteligência em Agravos Tropicais Emergentes e Negligenciados, Teresina (PI), Brasil., Ibiapina AB; Centro de Inteligência em Agravos Tropicais Emergentes e Negligenciados Teresina (PI) Brasil Centro de Inteligência em Agravos Tropicais Emergentes e Negligenciados, Teresina (PI), Brasil., da Silva CO; Universidade Federal do Piauí Programa de Mestrado em Ciências e Saúde Teresina (PI) Brasil Universidade Federal do Piauí, Programa de Mestrado em Ciências e Saúde, Teresina (PI), Brasil., Costa JO; Universidade Federal do Piauí Programa de Mestrado em Ciências e Saúde Teresina (PI) Brasil Universidade Federal do Piauí, Programa de Mestrado em Ciências e Saúde, Teresina (PI), Brasil., Tajra FS; Centro de Inteligência em Agravos Tropicais Emergentes e Negligenciados Teresina (PI) Brasil Centro de Inteligência em Agravos Tropicais Emergentes e Negligenciados, Teresina (PI), Brasil., Abdala CVM; Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde (BIREME) São Paulo (SP) Brasil Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde (BIREME), São Paulo (SP), Brasil.
Jazyk:	portugalština
Zdroj:	Revista panamericana de salud publica = Pan American journal of public health [Rev Panam Salud Publica] 2024 Oct 18; Vol. 48, pp. e99. Date of Electronic Publication: 2024 Oct 18 (Print Publication: 2024).
DOI:	10.26633/RPSP.2024.99
Abstrakt:	Objective: Based on a review of the literature, to create a map of the available evidence on the treatment methods for chikungunya. Method: In May 2022, a literature search on chikungunya was conducted using the PubMed and Virtual Health Library platforms. To create the evidence map, studies that mentioned chikungunya fever were selected and characterized based on the type of intervention, outcome, and direction of the effect (positive, negative, potentially positive or potentially negative, inconclusive, or no effect), following the methodology recommended by the Latin American and Caribbean Center on Health Sciences Information (BIREME). Results: Fifteen studies (systematic reviews, controlled clinical trials, and narrative reviews) with both pharmacological and non-pharmacological interventions were included. All interventions focused on symptom mitigation; no study specifically investigated ways to combat the virus itself. Only one study on pharmacological interventions reported a positive effect, involving monotherapy with hydroxychloroquine and combined therapy with methotrexate plus sulfasalazine and hydroxychloroquine for reducing and relieving pain caused by post-chikungunya arthritis. The only study to report a negative effect described the use of chloroquine for post-chikungunya arthralgia. Among non-pharmacological interventions, positive effects were noted for transcranial direct current stimulation, elastic band exercises, and the Pilates method, particularly for pain relief and improvement of joint function. Conclusion: Although the review did not identify any treatments that act directly on the virus after the onset of the disease, the evidence map suggests that it is possible to treat the symptoms and sequelae of chikungunya with both pharmacological and non-pharmacological therapies.
Databáze:	MEDLINE
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