| Autor: |
Donsakul N; Southern Regional Hospital of Tropical Dermatology-Trang Province, Department of Medical Services, Ministry of Public Health, Trang 92000, Thailand., Jerasutus S; Division of Dermatology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand., Tubtieng I; Phatthalung Hospital, Phatthalung 93000, Thailand., Assavanatenapa R; Institute of Dermatology, Department of Medical Services, Ministry of Public Health, Bangkok 10400, Thailand., Vejjabhinanta V; Southern Regional Hospital of Tropical Dermatology-Trang Province, Department of Medical Services, Ministry of Public Health, Trang 92000, Thailand. |
| Jazyk: |
angličtina |
| Zdroj: |
Dermatopathology (Basel, Switzerland) [Dermatopathology (Basel)] 2024 Oct 20; Vol. 11 (4), pp. 286-292. Date of Electronic Publication: 2024 Oct 20. |
| DOI: |
10.3390/dermatopathology11040030 |
| Abstrakt: |
Undifferentiated pleomorphic sarcoma (UPS) is an aggressive soft tissue sarcoma with a poor prognosis. The patients are usually found to have metastasis when the primary tumor is diagnosed. Eccrine syringofibroadenoma (ESFA) is a rare cutaneous adnexal lesion of eccrine duct origin. There are five subtypes, one of which is reactive ESFA, known to occur in reaction to an inflammatory or neoplastic process. In this article, we report a case of the co-existence of both UPS and ESFA in a 70-year-old male patient, presenting with a painless, erythematous, irregular surface nodule with a peripherally extended brownish hyperkeratotic plaque on the right palm. The histologic findings revealed an ill-defined dermal tumor of atypical epithelioid and spindle-shaped cells with large pleomorphic hyperchromatic nuclei and abundant eosinophilic cytoplasm. Some of those cells were multinucleated giant cells in the stroma with vascular proliferation and mixed inflammatory cell infiltrate. The tumor cells, which were only positive for vimentin, supported the diagnosis of undifferentiated pleomorphic sarcoma (UPS). Meanwhile, the overlying epidermis demonstrated hyperkeratosis, papillated epidermal hyperplasia, and proliferation of anastomosing slender cords and strands of cuboid cells within loose fibrovascular stroma. These findings are the characteristics of eccrine syringofibroadenoma (ESFA). We describe here a patient in whom reactive ESFA occurred on and surrounded the UPS tumor. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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