The Value of Reducing Inconclusive and False-Positive Newborn Screening Results for Congenital Hypothyroidism, Congenital Adrenal Hyperplasia and Maple Syrup Urine Disease in The Netherlands.

Autor:	Martens RC; Endocrine Laboratory, Department of Laboratory Medicine, Amsterdam University Medical Centers, Location University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.; Endocrine Laboratory, Department of Laboratory Medicine, Amsterdam University Medical Centers, Location Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.; Amsterdam Gastroenterology, Endocrinology & Metabolism, 1105 AZ Amsterdam, The Netherlands., Boelen A; Endocrine Laboratory, Department of Laboratory Medicine, Amsterdam University Medical Centers, Location University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.; Amsterdam Gastroenterology, Endocrinology & Metabolism, 1105 AZ Amsterdam, The Netherlands.; Amsterdam Reproduction and Development Research Institute, 1105 AZ Amsterdam, The Netherlands., van der Kemp MH; Value-Based Healthcare Strategy & Tactics, VDKMP, 1017 XP Amsterdam, The Netherlands., Bosch AM; Amsterdam Gastroenterology, Endocrinology & Metabolism, 1105 AZ Amsterdam, The Netherlands.; Amsterdam Reproduction and Development Research Institute, 1105 AZ Amsterdam, The Netherlands.; Department of Pediatrics, Division of Metabolic Diseases, Emma Children's Hospital, Amsterdam University Medical Centers, Location University of Amsterdam, 1105 AZ Amsterdam, The Netherlands., Berghout EM; Department of Pediatrics, Deventer Ziekenhuis, 7417 SE Deventer, The Netherlands., Weijman G; Department for Vaccine Supply and Prevention Programs, RIVM Dutch National Institute for Public Health and the Environment, 3720 BA Bilthoven, The Netherlands., Zwaveling-Soonawala N; Amsterdam Gastroenterology, Endocrinology & Metabolism, 1105 AZ Amsterdam, The Netherlands.; Department of Pediatric Endocrinology, Emma Children's Hospital, Amsterdam University Medical Centers, Location University of Amsterdam, 1105 AZ Amsterdam, The Netherlands., Verschoof-Puite RK; Department for Vaccine Supply and Prevention Programs, RIVM Dutch National Institute for Public Health and the Environment, 3720 BA Bilthoven, The Netherlands., de Jonge R; Amsterdam Gastroenterology, Endocrinology & Metabolism, 1105 AZ Amsterdam, The Netherlands.; Department of Laboratory Medicine, Amsterdam University Medical Centers, Location University of Amsterdam, 1105 AZ Amsterdam and Location Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands., Hannema SE; Amsterdam Gastroenterology, Endocrinology & Metabolism, 1105 AZ Amsterdam, The Netherlands.; Amsterdam Reproduction and Development Research Institute, 1105 AZ Amsterdam, The Netherlands.; Department of Pediatrics, Amsterdam University Medical Centers, Location Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands., Bosmans JE; Department of Health Sciences, Faculty of Science, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands., Heijboer AC; Endocrine Laboratory, Department of Laboratory Medicine, Amsterdam University Medical Centers, Location University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.; Endocrine Laboratory, Department of Laboratory Medicine, Amsterdam University Medical Centers, Location Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.; Amsterdam Gastroenterology, Endocrinology & Metabolism, 1105 AZ Amsterdam, The Netherlands.; Amsterdam Reproduction and Development Research Institute, 1105 AZ Amsterdam, The Netherlands.
Jazyk:	angličtina
Zdroj:	International journal of neonatal screening [Int J Neonatal Screen] 2024 Oct 08; Vol. 10 (4). Date of Electronic Publication: 2024 Oct 08.
DOI:	10.3390/ijns10040070
Abstrakt:	Inconclusive and false-positive newborn screening (NBS) results can cause parental stress and increase healthcare expenditures. These results can be reduced by improving NBS algorithms. This was recently done for Congenital Hypothyroidism (CH), Congenital Adrenal Hyperplasia (CAH) and Maple Syrup Urine Disease (MSUD) in the Dutch NBS program. The current study estimates the financial consequences of these improved algorithms related to the reduction in inconclusive results and false-positives. For each improved algorithm, the care pathway of an inconclusive/false-positive result was analyzed. The costs associated with the improvements, based on the change in inconclusive results/false-positives, were assessed to estimate the cost reduction per year. The improvements resulted in a reduction of inconclusive results and/or false-positives, without increasing false-negatives. For CH, false positives decreased by 26 per year with a related cost reduction of EUR 31,156. For CAH, 95 second heel punctures and seven false-positives per year were avoided, leading to a related cost reduction of EUR 7340. For MSUD, five false-positives per year were avoided with a related cost reduction of EUR 11,336. The improved screening algorithms led to a cost reduction of EUR 49,832 annually. Together with the known negative psychosocial effects associated with an inconclusive or false-positive NBS result, these results highlight the importance of improving NBS algorithms.
Databáze:	MEDLINE
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