A Wearable, Steerable, Transcranial Low-Intensity Focused Ultrasound System.

Autor: Bawiec CR; Openwater, San Francisco, California, USA., Hollender PJ; Openwater, San Francisco, California, USA., Ornellas SB; Openwater, San Francisco, California, USA., Schachtner JN; Department of Psychology, University of Arizona, Tucson, Arizona, USA., Dahill-Fuchel JF; Department of Psychology, University of Arizona, Tucson, Arizona, USA., Konecky SD; Openwater, San Francisco, California, USA., Allen JJB; Department of Psychology, University of Arizona, Tucson, Arizona, USA.
Jazyk: angličtina
Zdroj: Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine [J Ultrasound Med] 2024 Oct 24. Date of Electronic Publication: 2024 Oct 24.
DOI: 10.1002/jum.16600
Abstrakt: Objectives: Transcranial low-intensity focused ultrasound (LIFU) offers unique opportunities for precisely neuromodulating small and/or deep targets within the human brain, which may be useful for treating psychiatric and neurological disorders. This article presents a novel ultrasound system that delivers focused ultrasound through the forehead to anterior brain targets and evaluates its safety and usability in a volunteer study.
Methods: The ultrasound system and workflow are described, including neuronavigation, LIFU planning, and ultrasound delivery components. Its capabilities are analyzed through simulations and experiments in water to establish its safe steering range. A cohort of 20 healthy volunteers received a LIFU protocol aimed at the anterior medial prefrontal cortex (amPFC), using imaging and questionnaires to screen for adverse effects. Additional development after the study also analyzes the effect of the skull and sinus cavities on delivered ultrasound energy.
Results: Simulations and hydrophone readings agreed with <5% error, and the safe steering range was found to encompass a 1.8 cm × 2.5 cm × 2 cm volume centered at a depth 5 cm from the surface of the skin. There were no adverse effects evident on qualitative assessments, nor any signs of damage in susceptibility-weighted imaging scans. All participants tolerated the treatment well. The interface effectively enabled the users to complete the workflow with all participants. In particular, the amPFC of every participant was within the steering limits of the system. A post hoc analysis showed that "virtual fitting" could aid in steering the beams around subjects' sinuses.
Conclusions: The presented system safely delivered LIFU through the forehead while targeting the amPFC in all volunteers, and was well-tolerated. With the capabilities validated here and positive results of the study, this technology appears well-suited to explore LIFU's efficacy in clinical neuromodulation contexts.
(© 2024 The Author(s). Journal of Ultrasound in Medicine published by Wiley Periodicals LLC on behalf of American Institute of Ultrasound in Medicine.)
Databáze: MEDLINE
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