A prediction model for electroconvulsive therapy effectiveness in patients with major depressive disorder from the Dutch ECT Consortium (DEC).

Autor: Loef D; Amsterdam UMC, location Vrije Universiteit Amsterdam, Department of Psychiatry, Boelelaan 1117, Amsterdam, The Netherlands. d.loef@ggzingeest.nl.; Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress program, Amsterdam, The Netherlands. d.loef@ggzingeest.nl.; GGZ inGeest Mental Health Care, Amsterdam, The Netherlands. d.loef@ggzingeest.nl., Hoogendoorn AW; Amsterdam UMC, location Vrije Universiteit Amsterdam, Department of Psychiatry, Boelelaan 1117, Amsterdam, The Netherlands.; Amsterdam Public Health, Mental Health program, Amsterdam, The Netherlands., Somers M; Department of Psychiatry, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Mocking RJT; Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress program, Amsterdam, The Netherlands.; Amsterdam UMC, University of Amsterdam, Department of Psychiatry, Amsterdam, The Netherlands., Scheepens DS; Amsterdam UMC, University of Amsterdam, Department of Psychiatry, Amsterdam, The Netherlands., Scheepstra KWF; Amsterdam UMC, University of Amsterdam, Department of Psychiatry, Amsterdam, The Netherlands.; Neuroimmunology research group, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands.; Psychiatric Program of the Netherlands Brain Bank, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands., Blijleven M; Department of Psychiatry, St Antonius Hospital, Utrecht, The Netherlands., Hegeman JM; Department of Psychiatry, St Antonius Hospital, Utrecht, The Netherlands., van den Berg KS; Department of Psychiatry, St Antonius Hospital, Utrecht, The Netherlands., Schut B; Depression Patient Organization, Amersfoort, The Netherlands.; Patient Advisory Board, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Birkenhager TK; Department of Psychiatry, Erasmus UMC, Rotterdam, The Netherlands., Heijnen W; Department of Psychiatry, Erasmus UMC, Rotterdam, The Netherlands., Rhebergen D; Amsterdam UMC, location Vrije Universiteit Amsterdam, Department of Psychiatry, Boelelaan 1117, Amsterdam, The Netherlands.; Department of Research, GGZ Centraal Mental Health Care, Amersfoort, The Netherlands., Oudega ML; Amsterdam UMC, location Vrije Universiteit Amsterdam, Department of Psychiatry, Boelelaan 1117, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress program, Amsterdam, The Netherlands.; GGZ inGeest Mental Health Care, Amsterdam, The Netherlands., Schouws SNTM; Amsterdam UMC, location Vrije Universiteit Amsterdam, Department of Psychiatry, Boelelaan 1117, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress program, Amsterdam, The Netherlands.; GGZ inGeest Mental Health Care, Amsterdam, The Netherlands., van Exel E; Amsterdam UMC, location Vrije Universiteit Amsterdam, Department of Psychiatry, Boelelaan 1117, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress program, Amsterdam, The Netherlands.; GGZ inGeest Mental Health Care, Amsterdam, The Netherlands., Rutten BPF; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands., Broekman BFP; Amsterdam UMC, location Vrije Universiteit Amsterdam, Department of Psychiatry, Boelelaan 1117, Amsterdam, The Netherlands.; Department of Psychiatry and Medical Psychology, OLVG, Amsterdam, The Netherlands., Vergouwen ACM; Department of Psychiatry and Medical Psychology, OLVG, Amsterdam, The Netherlands., Zoon TJC; Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress program, Amsterdam, The Netherlands., Kok RM; Department of Old Age Psychiatry, Parnassia Psychiatric Institute, The Hague, The Netherlands., Somers K; Department of ECT, Parnassia Psychiatric Institute, The Hague, The Netherlands., Verwijk E; Department of ECT, Parnassia Psychiatric Institute, The Hague, The Netherlands.; University of Amsterdam, Department of Psychology, Brain and Cognition, Amsterdam, The Netherlands.; Amsterdam UMC, location Academic Medical Center, Department of Medical Psychology, Amsterdam, The Netherlands., Rovers JJE; Donders Institute for Brain, Cognition and Behavior, Department of Psychiatry, Nijmegen, The Netherlands.; Department of Psychiatry, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands., Schuur G; Department of Psychiatry, Rijnstate Hospital, Arnhem, The Netherlands., van Waarde JA; Department of Psychiatry, Rijnstate Hospital, Arnhem, The Netherlands., Verdijk JPAJ; Department of Psychiatry, Rijnstate Hospital, Arnhem, The Netherlands.; Technical Medical Centre, Faculty of Science and Technology, Clinical Neurophysiology, University of Twente, Enschede, The Netherlands., Bloemkolk D; Department of Psychiatry, Tergooi MC, Hilversum, The Netherlands., Gerritse FL; Department of Psychiatry, Tergooi MC, Hilversum, The Netherlands., van Welie H; Department of Psychiatry, Tergooi MC, Hilversum, The Netherlands., Haarman BCM; Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., van Belkum SM; Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Vischjager M; Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Hagoort K; Department of Psychiatry, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., van Dellen E; Department of Psychiatry, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.; Department of Neurology, UZ Brussel and Vrije Universiteit Brussel, Brussels, Belgium., Tendolkar I; Donders Institute for Brain, Cognition and Behavior, Department of Psychiatry, Nijmegen, The Netherlands.; Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Psychiatry and Psychotherapy, University Hospital Essen, Essen, Germany., van Eijndhoven PFP; Donders Institute for Brain, Cognition and Behavior, Department of Psychiatry, Nijmegen, The Netherlands.; Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands., Dols A; Amsterdam UMC, location Vrije Universiteit Amsterdam, Department of Psychiatry, Boelelaan 1117, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress program, Amsterdam, The Netherlands.; Department of Psychiatry, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Jazyk: angličtina
Zdroj: Molecular psychiatry [Mol Psychiatry] 2024 Oct 24. Date of Electronic Publication: 2024 Oct 24.
DOI: 10.1038/s41380-024-02803-2
Abstrakt: Reliable predictors for electroconvulsive therapy (ECT) effectiveness would allow a more precise and personalized approach for the treatment of major depressive disorder (MDD). Prediction models were created using a priori selected clinical variables based on previous meta-analyses. Multivariable linear regression analysis was used, applying backwards selection to determine predictor variables while allowing non-linear relations, to develop a prediction model for depression outcome post-ECT (and logistic regression for remission and response as secondary outcome measures). Internal validation and internal-external cross-validation were used to examine overfitting and generalizability of the model's predictive performance. In total, 1892 adult patients with MDD were included from 22 clinical and research cohorts of the twelve sites within the Dutch ECT Consortium. The final primary prediction model showed several factors that significantly predicted a lower depression score post-ECT: higher age, shorter duration of the current depressive episode, severe MDD with psychotic features, lower level of previous antidepressant resistance in the current episode, higher pre-ECT global cognitive functioning, absence of a comorbid personality disorder, and a lower level of failed psychotherapy in the current episode. The optimism-adjusted R² of the final model was 19%. This prediction model based on readily available clinical information can reduce uncertainty of ECT outcomes and hereby inform clinical decision-making, as prompt referral for ECT may be particularly beneficial for individuals with the above-mentioned characteristics. However, despite including a large number of pretreatment factors, a large proportion of the variance in depression outcome post-ECT remained unpredictable.
(© 2024. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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