| Autor: |
Yao H; Department of Urology, Zhongnan Hospital of Wuhan University, Cancer Precision Diagnosis and Treatment and Translational Medicine Hubei Engineering Research Center, Wuhan 430072, P. R. China., You X; College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China., Ye Y; College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China., Gong X; College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China., Zhang X; College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China., Wang Y; Department of Urology, Zhongnan Hospital of Wuhan University, Cancer Precision Diagnosis and Treatment and Translational Medicine Hubei Engineering Research Center, Wuhan 430072, P. R. China., Zhou X; College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China., Li Y; College of Chemistry and Chemical Engineering, Central South University, Changsha 410000, P. R. China., Liu Y; Department of Urology, Zhongnan Hospital of Wuhan University, Cancer Precision Diagnosis and Treatment and Translational Medicine Hubei Engineering Research Center, Wuhan 430072, P. R. China., Dutta Chowdhury A; College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China., Liu T; Department of Urology, Zhongnan Hospital of Wuhan University, Cancer Precision Diagnosis and Treatment and Translational Medicine Hubei Engineering Research Center, Wuhan 430072, P. R. China. |
| Abstrakt: |
The global demand for dialysis among patients with end-stage kidney disease has surpassed the capacity of public healthcare, a trend that has intensified. While wearable artificial kidney (WAK) technology is seen as a crucial solution to address this demand, there is an urgent need for both efficient and renewable toxin-adsorbent materials to overcome the long-standing technological challenges in terms of cost, device size, and sustainability. In this study, we employed screening experiments for adsorbent materials, multimodal characterization, and Monte Carlo adsorption simulations to identify a synthetic self-assembly silicalite-1 zeolite that exhibits highly ordered crystal arrays along the [010] face ( b -axis) direction, demonstrating exceptional adsorption capabilities for small molecular toxins such as creatinine and urea associated with uremia. Moreover, this metal-free, cost-effective, easily synthesized, and highly efficient toxin adsorbent could be regenerated through calcination without compromising the performance. The simulated toxin adsorption experiments and comprehensive biocompatibility verification position it as an auxiliary adsorbent to reduce dialysate dosages in WAK devices as well as a potential adsorbent for small-molecule toxins in dialysis. This work is poised to propel the development of next-generation WAK devices by providing siliceous adsorbent solutions for small-molecule toxins. |
