Efficacy of gabapentin and pregabalin for treatment of post refractive surgery pain: a systematic review and meta-analysis.

Autor: Chen KY; School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan., Chan HC; School of Pharmacy, China Medical University, Taichung, Taiwan., Wei LY; Department of Pharmacy, Cardinal Tien Hospital, New Taipei City, Taiwan. amyweiitw@gmail.com., Chan CM; Department of Ophthalmology, Cardinal Tien Hospital, New Taipei City, Taiwan. m212092001@tmu.edu.tw.; School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan. m212092001@tmu.edu.tw.
Jazyk: angličtina
Zdroj: International ophthalmology [Int Ophthalmol] 2024 Oct 24; Vol. 44 (1), pp. 409. Date of Electronic Publication: 2024 Oct 24.
DOI: 10.1007/s10792-024-03300-9
Abstrakt: Introduction: For ophthalmic patients, eye discomfort is a major problem that requires efficient pain treatment techniques. Pregabalin and gabapentin have surfaced as viable treatments for post-refractive surgery pain. To manage pain after refractive surgery, gabapentin and pregabalin were evaluated in this systematic review and meta-analysis.
Methodology: A thorough search of databases including PubMed, Embase, Cochrane Library, and CINAHL was performed until March 2024. Inclusion criteria were randomized controlled trials assessing pregabalin and/or gabapentin's effectiveness in treating pain post-PRK, LASIK, and LASEK surgeries.
Results: Six studies met inclusion criteria, comprising a total of 391 patients undergoing various corneal surgeries. The meta-analysis revealed that pregabalin was significantly more effective than placebo in reducing pain on the first and second postoperative days (SMD day 1: -0.32, 95% CI -0.54, -0.09; SMD day 2: -0.55, 95% CI -0.85, -0.25), while gabapentin showed significant pain reduction on the second day only (SMD day 2: -0.42, 95% CI -0.71, -0.13). Combined analysis for both medications showed significant pain reduction on the first- and second-days post-surgery. No significant increase in adverse events was associated with either medication. Publication bias was minimal except for a slight asymmetry noted on day 1 effectiveness.
Conclusion: Pregabalin and gabapentin are effective in reducing postoperative pain following refractive surgeries, with pregabalin showing a greater effect. Both medications are safe, with no significant increase in adverse events. Further research with standardized methodologies and long-term follow-up is recommended to optimize postoperative pain management in ocular surgeries.
(© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
Databáze: MEDLINE
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