Exploratory evidence maps for the WHO Classification of Tumours 5th edition for lung and thymus tumors.

Autor: Giesen C; Evidence Synthesis Branch, International Agency for Research On Cancer (IARC), World Health Organization, 25 Avenue Tony Garnier, CS 90627, 69366, CEDEX 07, LYON, France. giesenc@iarc.who.int., Del Águila Mejía J; Evidence Synthesis Branch, International Agency for Research On Cancer (IARC), World Health Organization, 25 Avenue Tony Garnier, CS 90627, 69366, CEDEX 07, LYON, France.; Centro Nacional de Epidemiología, Instituto de Salud Carlos IIII, Calle de Melchor Fernández Almagro 5, 28029, Madrid, Spain., Armon S; Evidence Synthesis Branch, International Agency for Research On Cancer (IARC), World Health Organization, 25 Avenue Tony Garnier, CS 90627, 69366, CEDEX 07, LYON, France.; Hospital Kuala Lumpur, Ministry of Health, W.P. Kuala Lumpur, Malaysia., Cierco Jimenez R; Evidence Synthesis Branch, International Agency for Research On Cancer (IARC), World Health Organization, 25 Avenue Tony Garnier, CS 90627, 69366, CEDEX 07, LYON, France., Myles N; Evidence Synthesis Branch, International Agency for Research On Cancer (IARC), World Health Organization, 25 Avenue Tony Garnier, CS 90627, 69366, CEDEX 07, LYON, France.; St Paul's Hospital, Providence Health, Vancouver, BC, Canada., Goldman-Lévy G; Evidence Synthesis Branch, International Agency for Research On Cancer (IARC), World Health Organization, 25 Avenue Tony Garnier, CS 90627, 69366, CEDEX 07, LYON, France., Machado A; Evidence Synthesis Branch, International Agency for Research On Cancer (IARC), World Health Organization, 25 Avenue Tony Garnier, CS 90627, 69366, CEDEX 07, LYON, France., Indave I; Evidence Synthesis Branch, International Agency for Research On Cancer (IARC), World Health Organization, 25 Avenue Tony Garnier, CS 90627, 69366, CEDEX 07, LYON, France., Cree IA; Evidence Synthesis Branch, International Agency for Research On Cancer (IARC), World Health Organization, 25 Avenue Tony Garnier, CS 90627, 69366, CEDEX 07, LYON, France., Lokuhetty D; Evidence Synthesis Branch, International Agency for Research On Cancer (IARC), World Health Organization, 25 Avenue Tony Garnier, CS 90627, 69366, CEDEX 07, LYON, France.
Jazyk: angličtina
Zdroj: Virchows Archiv : an international journal of pathology [Virchows Arch] 2024 Nov; Vol. 485 (5), pp. 869-878. Date of Electronic Publication: 2024 Oct 25.
DOI: 10.1007/s00428-024-03886-6
Abstrakt: The WHO Classification of Tumours (WCT) guides cancer diagnosis, treatment, and research. However, research evidence in pathology continuously changes, and new evidence emerges. Correct assessment of evidence in the WCT 5th edition (WCT-5) and identification of high level of evidence (LOE) studies based on study design are needed to improve future editions. We aimed at producing exploratory evidence maps for WCT-5 Thoracic Tumours, specifically lung and thymus tumors. We extracted citations from WCT-5, and imported and coded them in EPPI-Reviewer. The maps were plotted using EPPI-Mapper. Maps displayed tumor types (columns), descriptors (rows), and LOE (bubbles using a four-color code). We included 1434 studies addressing 51 lung, and 677 studies addressing 25 thymus tumor types from WCT-5 thoracic tumours volume. Overall, 87.7% (n = 1257) and 80.8% (n = 547) references were low, and 4.1% (n = 59) and 2.2% (n = 15) high LOE for lung and thymus tumors, respectively. Invasive non-mucinous adenocarcinoma of the lung (n = 215; 15.0%) and squamous cell carcinoma of the thymus (n = 93; 13.7%) presented the highest number of references. High LOE was observed for colloid adenocarcinoma of the lung (n = 11; 18.2%) and type AB thymoma (n = 4; 1.4%). Tumor descriptors with the highest number of citations were prognosis and prediction (n = 273; 19.0%) for lung, and epidemiology (n = 186; 28.0%) for thymus tumors. LOE was generally low for lung and thymus tumors. This study represents an initial step in the WCT Evidence Gap Map (WCT-EVI-MAP) project for mapping references in WCT-5 for all tumor types to inform future WCT editions.
Competing Interests: Declarations Ethics approval and consent to participate Since we developed maps based on published literature and no patient was involved in this study, no Ethics Review Board approval was necessary. Conflict of interest The authors declare no competing interests.
(© 2024. World Health Organization and the Authors.)
Databáze: MEDLINE
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