Characteristics of long-term survivors with malignant pleural mesothelioma.

Autor:	Opitz I; Department of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland. Electronic address: isabelle.schmitt-opitz@usz.ch., Lauk O; Department of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland., Werner R; Department of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland., Matter A; Department of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland., Hebeisen M; Department of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland; Department of Biostatistics, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland., Battilana B; Department of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland., Batirel H; Department of Thoracic Surgery, Marmara University School of Medicine, Istanbul, Turkey., Pass H; Department of Cardiothoracic Surgery, General Thoracic Surgery, Langone's Perlmutter Cancer Center, New York City, USA., Flores R; Department of Thoracic Surgery, Mount Sinai Health System, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Wolf A; Department of Thoracic Surgery, Mount Sinai Health System, Icahn School of Medicine at Mount Sinai, New York, NY, USA., de Perrot M; Division of Thoracic Surgery, Department of Surgery, University of Toronto, Toronto, Canada., Hoda MA; Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria., Klepetko W; Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria., Klikovits T; Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria., Hashimoto M; Department of Thoracic Surgery, Hyogo Medical University, Hyogo, Japan., Hasegawa S; Department of Thoracic Surgery, Hyogo Medical University, Hyogo, Japan., Richards WG; Division of Thoracic and Cardiac Surgery, Brigham and Women's Hospital, Boston, USA., Bueno R; Division of Thoracic and Cardiac Surgery, Brigham and Women's Hospital, Boston, USA.
Jazyk:	angličtina
Zdroj:	The Annals of thoracic surgery [Ann Thorac Surg] 2024 Oct 22. Date of Electronic Publication: 2024 Oct 22.
DOI:	10.1016/j.athoracsur.2024.10.004
Abstrakt:	Background: Pleural mesothelioma (PM) is a cancer with usually a dismal prognosis. However, long-term survivors do exist. Herein, we analyzed long-term survivors (>5 years after surgery) from high-volume centres around the world. Methods: This is a multicenter retrospective descriptive analysis of long-term survivors (overall survival ≥ 5 years from surgery) treated within a multimodality therapy approach including macroscopic complete resection. Overall survival was calculated with Kaplan Meier analysis and cases were matched by center and surgery year and compared with a control group of short-term survivors (<2 years) in a conditional logistic regression analysis. Results: There were 276 long-term survivors, most were male (n=166, 63%) with a median age of 59 (range 21-83) years at time of diagnosis. The histology for 246 was epithelioid and non-epithelioid for 30 patients. The disease was on the right side in 58% of the patients. As of this analysis, 148 patients were dead, 104 were alive and 10 were lost to follow-up. Pathological tumor stages were: pT1 (n=50), pT2 (n=63), pT3 (n=90) or pT4 (n=16), pN0 (n=150), pN1 (n=20) and pN2 (n=39). The matched control dataset included 333 patients, 95 cases and 238 controls. Comparing short- with long-term survivors, there was moderate evidence that a low white blood cell (WBC) count before surgery was more often observed in long-term survivors. Conclusions: The data show that long-term survival in PM is possible in a subgroup of surgically treated patients; histological subtype and WBC count seem to be prognosticators for longer survival. (Copyright © 2024. Published by Elsevier Inc.)
Databáze:	MEDLINE
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