The role of enteric nervous system and GDNF in depression: Conversation between the brain and the gut.

Autor: Liang C; School of Nursing, Jinan University, Guangzhou, China., Wei S; School of Nursing, Jinan University, Guangzhou, China., Ji Y; School of Nursing, Jinan University, Guangzhou, China., Lin J; School of Nursing, Jinan University, Guangzhou, China., Jiao W; School of Nursing, Jinan University, Guangzhou, China., Li Z; School of Nursing, Jinan University, Guangzhou, China., Yan F; School of Nursing, Jinan University, Guangzhou, China. Electronic address: yanfengxia0807@163.com., Jing X; School of Nursing, Jinan University, Guangzhou, China; Guangdong-Hong Kong-Macau Great Bay Area Geoscience Joint Laboratory, School of Medicine, Jinan University, Guangzhou, China. Electronic address: jingxi@jun.edu.cn.
Jazyk: angličtina
Zdroj: Neuroscience and biobehavioral reviews [Neurosci Biobehav Rev] 2024 Dec; Vol. 167, pp. 105931. Date of Electronic Publication: 2024 Oct 23.
DOI: 10.1016/j.neubiorev.2024.105931
Abstrakt: Depression is a debilitating mental disorder that causes a persistent feeling of sadness and loss of interest. Approximately 280 million individuals worldwide suffer from depression by 2023. Despite the heavy medical and social burden imposed by depression, pathophysiology remains incompletely understood. Emerging evidence indicates various bidirectional interplay enable communication between the gut and brain. These interplays provide a link between intestinal and central nervous system as well as feedback from cortical and sensory centers to enteric activities, which also influences physiology and behavior in depression. This review aims to overview the significant role of the enteric nervous system (ENS) in the pathophysiology of depression and gut-brain axis's contribution to depressive disorders. Additionally, we explore the alterations in enteric glia cells (EGCs) and glial cell line-derived neurotrophic factor (GDNF) in depression and their involvement in neuronal support, intestinal homeostasis maintains and immune response activation. Modulating ENS function, EGCs and GDNF level could serve as novel strategies for future antidepressant therapy.
Competing Interests: Declaration of Competing Interest All authors declare no conflict of interest.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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