A blood-based PT-LIFE (Pediatric Liver Transplantation-LIver Fibrosis Evaluation) biomarker panel for noninvasive evaluation of pediatric liver fibrosis after liver transplantation: A prospective derivation and validation study.

Autor:	Lv Z; Department of Liver Surgery, Renji Hospital (Punan Branch), School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Clinical Research Unit, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China., Yong JK; Department of Liver Surgery, Renji Hospital (Punan Branch), School of Medicine, Shanghai Jiao Tong University, Shanghai, China., Liu Y; Department of Liver Surgery, Renji Hospital (Punan Branch), School of Medicine, Shanghai Jiao Tong University, Shanghai, China., Zhou Y; Department of Liver Surgery, Renji Hospital (Punan Branch), School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Shanghai Engineering Research Centre of Transplantation and Immunology, Shanghai, China., Pan Y; Shanghai Engineering Research Centre of Transplantation and Immunology, Shanghai, China., Xiang X; Shanghai Engineering Research Centre of Transplantation and Immunology, Shanghai, China., Li L; Shanghai Engineering Research Centre of Transplantation and Immunology, Shanghai, China., Wang Y; Shanghai Engineering Research Centre of Transplantation and Immunology, Shanghai, China., Zhao Y; Department of General, Visceral, Cancer and Transplantation Surgery, University Hospital Cologne, Cologne, Germany., Liu Z; Shanghai Engineering Research Centre of Transplantation and Immunology, Shanghai, China., Zhang Z; Shanghai Engineering Research Centre of Transplantation and Immunology, Shanghai, China. Electronic address: sjtuzzj@sjtu.edu.cn., Xia Q; Department of Liver Surgery, Renji Hospital (Punan Branch), School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Shanghai Engineering Research Centre of Transplantation and Immunology, Shanghai, China. Electronic address: xiaqiang@medmail.com.cn., Feng H; Department of Liver Surgery, Renji Hospital (Punan Branch), School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Clinical Research Unit, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Shanghai Engineering Research Centre of Transplantation and Immunology, Shanghai, China. Electronic address: surgeonfeng@live.com.
Jazyk:	angličtina
Zdroj:	American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2024 Oct 22. Date of Electronic Publication: 2024 Oct 22.
DOI:	10.1016/j.ajt.2024.10.012
Abstrakt:	Allograft fibrosis is increasingly detected in graft biopsies as the postoperative period extends, potentially emerging as a pivotal determinant of long-term graft function and graft survival among pediatric recipients. Currently, there is a paucity of noninvasive diagnostic tools capable of identifying allograft fibrosis in pediatric recipients of liver transplants. This study involved 507 pediatric liver transplant patients and developed a novel blood-based diagnostic assay, Pediatric Liver Transplantation-Liver Fibrosis Evaluation (PT-LIFE), to noninvasively distinguish allograft fibrosis using blood samples, clinical data, and biopsy outcomes. The PT-LIFE assay was derived from a matrix of 23 variables and validated in 2 independent cohorts. It integrates 3 biomarkers (LECT2, YKL-40, FBLN3) with an area under the receiver operating characteristic curve of 0.91. In the pooled analysis, a PT-LIFE score lower than 0.12 identified liver allograft fibrosis semiquantitative scores 0 to 2 with a sensitivity of 91.9%, whereas scores above 0.29 indicated liver allograft fibrosis semiquantitative scores 3 to 6, with a specificity of 88.4%. The PT-LIFE assay presents as a promising noninvasive diagnostic tool for the detection of allograft fibrosis in pediatric liver transplant recipients. Competing Interests: Declaration of competing interest The authors of this manuscript have no conflicts of interest to disclose as described by the American Journal of Transplantation. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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