Native corn (Zea mays L., cv. 'Elotes Occidentales') polyphenols extract reduced total cholesterol and triglycerides levels, and decreased lipid accumulation in mice fed a high-fat diet.

Autor: Lee-Martínez SN; Advanced Biomedical Research Center, School of Medicine, Universidad Autónoma de Querétaro, Querétaro, Qro 76140, México., Luzardo-Ocampo I; Tecnologico de Monterrey, The Institute for Obesity Research, Ave. Eugenio Garza Sada 2501 Sur, Col: Tecnológico, Monterrey, 64700 N. L., Mexico; Tecnologico de Monterrey, School of Enginering and Sciences, Av. Gral. Ramon Corona 2514, Zapopan, 45201 Jal., Mexico. Electronic address: ivanluzardo@tec.mx., Vergara-Castañeda HA; Advanced Biomedical Research Center, School of Medicine, Universidad Autónoma de Querétaro, Querétaro, Qro 76140, México., Vasco-Leal JF; Posgrado de Gestión Tecnológica e Innovación, Universidad Autónoma de Querétaro, Querétaro, Qro 76010, México., Gaytán-Martínez M; Research and Graduate Program in Food Science, Universidad Autónoma de Querétaro, Querétaro, Qro 76010, México., Cuellar-Nuñez ML; Advanced Biomedical Research Center, School of Medicine, Universidad Autónoma de Querétaro, Querétaro, Qro 76140, México. Electronic address: liceth.cuellar@uaq.mx.
Jazyk: angličtina
Zdroj: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2024 Nov; Vol. 180, pp. 117610. Date of Electronic Publication: 2024 Oct 23.
DOI: 10.1016/j.biopha.2024.117610
Abstrakt: Obesity is a complex disease with numerous molecular and metabolic implications that could be prevented through proper diet and lifestyle. Native corn is a promissory underutilized plant species containing bioactive compounds that could reduce the impact of obesity. This research aimed to characterize and evaluate the anti-obesogenic effect of a polyphenols-rich extract of native corn ('Elotes Occidentales') in HFD-fed mice. The powdered extract was administered using gelatins to C57BL/6 J mice randomly divided into four groups (n:8/group) for 13 weeks: standard diet (SD) group, HFD group, HFD+200 mg extract/kg body weight (BW), and HFD+400 mg extract/kg BW/day. Ellagic acid, chlorogenic acid, rutin, and kaempferol were the most abundant phenolics (2022.44-4028.43 µg/g). Among the HFD groups, the highest dose of the extracts promoted the lowest BW gain, and fasting triglycerides and cholesterol levels. Moreover, the HFD+400 mg/kg BW group showed the lowest epididymal and subcutaneous adipose tissue weight and adipocytes' diameter and area between the HFD-treated animals. The extract administration prevented hepatic lipid accumulation. Rutin demonstrated the highest in silico binding affinity with proteins from the AMPK pathway (ACACA, SIRT1, and SREBP1) (-6.70 to -8.70 kcal/mol). Results indicated beneficial effects in alleviating obesity-associated parameters in vivo due to bioactive compounds from native maize extracts.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
Databáze: MEDLINE
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