Ti 3 C 2 T x -UHMWPE Nanocomposites-Towards an Enhanced Wear-Resistance of Biomedical Implants.

Autor: Rothammer B; Engineering Design, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany., Feile K; Engineering Design, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany., Werner S; Institute of Polymer Materials, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany., Frank R; Institute of Polymer Technology, Friedrich-Alexander-Universität Erlangen Nürnberg (FAU), Erlangen, Germany., Bartz M; Engineering Design, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany., Wartzack S; Engineering Design, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany., Schubert DW; Institute of Polymer Materials, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany., Drummer D; Institute of Polymer Technology, Friedrich-Alexander-Universität Erlangen Nürnberg (FAU), Erlangen, Germany., Detsch R; Department of Materials Science and Engineering, Institute of Biomaterials, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany., Wang B; Department of Functional Materials, Saarland University, Saarbrücken, Germany., Rosenkranz A; Department of Chemical Engineering, Biotechnology and Materials (FCFM), Universidad de Chile, Santiago, Chile.; ANID - Millennium Science Initiative Program, Millennium Nuclei of Advanced MXenes for Sustainable Applications (AMXSA), Santiago, Chile., Marian M; Department of Mechanical and Metallurgical Engineering, School of Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile.; Institute of Machine Design and Tribology (IMKT), Leibniz University Hannover, Garbsen, Germany.
Jazyk: angličtina
Zdroj: Journal of biomedical materials research. Part A [J Biomed Mater Res A] 2025 Jan; Vol. 113 (1), pp. e37819. Date of Electronic Publication: 2024 Oct 24.
DOI: 10.1002/jbm.a.37819
Abstrakt: There is an urgent need to enhance the mechanical and biotribological performance of polymeric materials utilized in biomedical devices such as load-bearing artificial joints, notably ultrahigh molecular weight polyethylene (UHMWPE). While two-dimensional (2D) materials like graphene, graphene oxide (GO), reduced GO, or hexagonal boron nitride (h-BN) have shown promise as reinforcement phases in polymer matrix composites (PMCs), the potential of MXenes, known for their chemical inertness, mechanical robustness, and wear-resistance, remains largely unexplored in biotribology. This study aims to address this gap by fabricating Ti 3 C 2 T x -UHMWPE nanocomposites using compression molding. Primary objectives include enhancements in mechanical properties, biocompatibility, and biotribological performance, particularly in terms of friction and wear resistance in cobalt chromium alloy pin-on-UHMWPE disk experiments lubricated by artificial synovial fluid. Thereby, no substantial changes in the indentation hardness or the elastic modulus are observed, while the analysis of the resulting wettability and surface tension as well as indirect and direct in vitro evaluation do not point towards cytotoxicity. Most importantly, Ti 3 C 2 T x -reinforced PMCs substantially reduce friction and wear by up to 19% and 44%, respectively, which was attributed to the formation of an easy-to-shear transfer film.
(© 2024 The Author(s). Journal of Biomedical Materials Research Part A published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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