A systematic analysis of neurologic manifestations of Long COVID in Nigeria.

Autor: Akase IE; Department of Medicine, Faculty of Clinical Sciences, College of Medicine, University of Lagos, Idi Araba, Lagos State, Nigeria.; Department of Medicine, Lagos University Teaching Hospital, Idi Araba, Lagos State, Nigeria., Agabi OP; Department of Medicine, Faculty of Clinical Sciences, College of Medicine, University of Lagos, Idi Araba, Lagos State, Nigeria.; Department of Medicine, Lagos University Teaching Hospital, Idi Araba, Lagos State, Nigeria., Ojo OO; Department of Medicine, Faculty of Clinical Sciences, College of Medicine, University of Lagos, Idi Araba, Lagos State, Nigeria.; Department of Medicine, Lagos University Teaching Hospital, Idi Araba, Lagos State, Nigeria., Anyanwu RA; Central Research Laboratory, College of Medicine, University of Lagos, Idi Araba, Lagos State, Nigeria., Awodumila S; Department of Medicine, Faculty of Clinical Sciences, College of Medicine, University of Lagos, Idi Araba, Lagos State, Nigeria., Ayilara S; Department of Medicine, Faculty of Clinical Sciences, College of Medicine, University of Lagos, Idi Araba, Lagos State, Nigeria., Ede OJ; Department of Medicine, Lagos University Teaching Hospital, Idi Araba, Lagos State, Nigeria., Ghajiga P; Department of Medicine, Faculty of Clinical Sciences, College of Medicine, University of Lagos, Idi Araba, Lagos State, Nigeria., Kalejaiye O; Department of Medicine, Faculty of Clinical Sciences, College of Medicine, University of Lagos, Idi Araba, Lagos State, Nigeria.; Department of Medicine, Lagos University Teaching Hospital, Idi Araba, Lagos State, Nigeria., Nwanmah C; Department of Medicine, Faculty of Clinical Sciences, College of Medicine, University of Lagos, Idi Araba, Lagos State, Nigeria., Nwaokorie F; Department of Medical Laboratory Science, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Idi Araba, Lagos State, Nigeria., Ogbenna A; Department of Hematology & Blood Transfusion, Faculty of Clinical Sciences, College of Medicine, University of Lagos, Idi Araba, Lagos State, Nigeria., Olajide M; Department of Medicine, Faculty of Clinical Sciences, College of Medicine, University of Lagos, Idi Araba, Lagos State, Nigeria., Perez-Giraldo GS; Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Orban ZS; Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Jimenez M; Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Koralnik IJ; Division of Neuro-Infectious Diseases and Global Neurology, Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. igor.koralnik@northwestern.edu., Okubadejo NU; Department of Medicine, Faculty of Clinical Sciences, College of Medicine, University of Lagos, Idi Araba, Lagos State, Nigeria.; Department of Medicine, Lagos University Teaching Hospital, Idi Araba, Lagos State, Nigeria.
Jazyk: angličtina
Zdroj: Journal of neurovirology [J Neurovirol] 2024 Oct 24. Date of Electronic Publication: 2024 Oct 24.
DOI: 10.1007/s13365-024-01232-9
Abstrakt: Long COVID, also called post-acute sequelae of SARS-CoV-2 infection (PASC) affects millions of people in the world. The neurologic manifestations of PASC (Neuro-PASC) are among the most debilitating but they are largely unreported in Africa. We sought to compare the demographics, symptoms and cognitive profile of post-hospitalization Neuro-PASC (PNP) and non-hospitalized Neuro-PASC (NNP) patients in Nigeria. In this cross-sectional study performed at the Lagos University Teaching Hospital, 106/2319 (4.6%) SARS-CoV-2 positive individuals contacted via telephone reported Neuro-PASC symptoms with a higher frequency in PNP than in NNP individuals ((23/200 (11.5%) vs. 83/2119 (3.9%), p = < 0.0001). The predominant neurologic symptoms at any time during the disease course were difficulty remembering / brain fog (63/106; 59.4%), fatigue (59/106; 55.7%), sleep problems (34/106; 32%), headache (33/106; 31%), paresthesia (12/106; 11.3%), and myalgia (10/106; 9.4%). Of 66 participants with Neuro-PASC who underwent in-person neurological evaluation and cognitive screening, all had normal scores on the Intervention for Dementia in Elderly Africans cognition screen, while 11/65 (16.9%) that completed the Montreal Cognitive Assessment had results consistent with mild cognitive impairment (3/16 PNP (18.8%) and 8/49 NNP (16.3%); p = 1.0). Finally, 47/66 (71.2%) had digit span test scores consistent with mild cognitive dysfunction (12/16 PNP (75%) and 35/50 (70%) NNP; p = 1.0). Our findings reveal the previously unrecognized occurrence of Neuro-PASC among COVID-19 survivors in Nigeria and highlight the need for improved screening and diagnosis of Neuro-PASC in our population. Development of cognitive support services for persons suffering from Neuro-PASC in Nigeria is warranted.
(© 2024. The Author(s) under exclusive licence to The Journal of NeuroVirology, Inc.)
Databáze: MEDLINE
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