Combination therapy of systemic and local metformin improves imiquimod-induced psoriasis-like lesions with type 2 diabetes: the role of AMPK/KGF/STAT3 axis.

Autor:	Hassan FE; Department of Physiology, Faculty of Medicine, Cairo University, Egypt., Aboulhoda BE; Department of Anatomy and Embryology, Faculty of Medicine, Cairo University, Egypt., Mehesen MN; Department of Pharmacology, Faculty of Medicine, Cairo University, Egypt.; Department of Pharmacy Practice and Clinical Pharmacy, Faculty of Pharmacy, Future University in Egypt, Cairo, Egypt., El Din PM; Department of Pharmacology, Faculty of Medicine, Alexandria University, Egypt., Abdallah HA; Department of Anatomy and Embryology, Faculty of Medicine, Cairo University, Egypt., Bendas ER; Department of Pharmacy Practice and Clinical Pharmacy, Faculty of Pharmacy, Future University in Egypt, Cairo, Egypt., Ahmed Rashed L; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Egypt., Mostafa A; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Egypt., Amer MF; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Egypt., Abdel-Rahman M; Department of Physiology, Faculty of Medicine, Cairo University, Egypt., Alghamdi MA; Department of Anatomy, College of Medicine, King Khalid University, Abha, Saudi Arabia.; Genomics and Personalized Medicine Unit, The Center for Medical and Health Research, King Khalid University, Abha, Saudi Arabia., Shams Eldeen AM; Department of Physiology, Faculty of Medicine, Cairo University, Egypt.
Jazyk:	angličtina
Zdroj:	Archives of physiology and biochemistry [Arch Physiol Biochem] 2024 Oct 24, pp. 1-13. Date of Electronic Publication: 2024 Oct 24.
DOI:	10.1080/13813455.2024.2407547
Abstrakt:	Context: Insulin resistance and a disturbed lipid profile are common associations with type 2 diabetes mellitus (T2DM) and different skin diseases, particularly psoriasis (PsO). Objectives: We investigated potential therapeutic mechanisms of metformin in a murine animal model of psoriasiform lesions in T2DM. Materials and Methods: Forty-two rats were randomly divided into control, PsO, and type II DM (T2DM) groups. After confirmation of DM, the type II diabetic rats were allocated into T2DM+ PsO, T2DM+ PsO+ systemic metformin (S. met), T2DM+ PsO+ topical metformin (T. met)), and T2DM+ PsO + combined metformin (C. met). PsO was induced by topical imiquimod. Results: Systemic administration of the cornerstone antidiabetic drug, metformin, was able to improve insulin resistance and lipid profile. At molecular levels, both topical and systemic metformin significantly increased AMP-activated protein kinase (AMPK), and lowered keratinocyte growth factor (KGF) / "Signal transducer and activator of transcription" (STAT)3 protein levels, and the IL-17RA and IL-17RC gene expression. Conclusion: Although its glucose-controlling effect was not optimum, T.met gel served anti-psoriatic and anti-inflammatory effects.
Databáze:	MEDLINE
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