Hepatitis B Virus-Associated Liver Carcinoma: The Role of Iron Metabolism and Its Modulation.

Autor: Ali I; Department of General Surgery, Subspecialty Hepatobiliary Surgery, Shanxi First Medical Hospital Affiliated With Shanxi Medical University, Yangzi Qu, Taiyuan, China., Muhammad S; Department of Urology, First Hospital of Shanxi Medical University, Yangzi Qu, Taiyuan, China., Naqvi SSZH; Department of Endocrinology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences; Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, China., Wei L; Laboratory of Physiology, Shanxi Medical University, Jing Zhong, China., Yan W; Shandong University, Ji Nan, Shandong, China., Khan MF; Department of Zoology, Hazara University, Mansehra, Khyber Pakhtunkhwa, Pakistan., Mahmood A; Department of Hepatobiliary and Echinococcosis Surgery, Digestive and Vascular Surgery Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China., Liu H; Department of General Surgery, Subspecialty Hepatobiliary Surgery, Shanxi First Medical Hospital Affiliated With Shanxi Medical University, Yangzi Qu, Taiyuan, China., Shah W; Translational Medicine Research Center, Shanxi Medical University, Taiyuan, China.; Shanxi Eye Hospital Affiliated to Shanxi Medical University, Taiyuan, China.
Jazyk: angličtina
Zdroj: Journal of viral hepatitis [J Viral Hepat] 2024 Oct 24. Date of Electronic Publication: 2024 Oct 24.
DOI: 10.1111/jvh.14016
Abstrakt: Hepatitis B virus (HBV) infection is a significant contributor to the development of hepatocellular carcinoma (HCC), a leading cause of cancer-related mortality worldwide. Iron, a central co-factor in various metabolic pathways, plays an essential role in liver function, but its dysregulation can lead to severe health consequences. Accumulation of iron within hepatic cells over time is linked to increased liver injury and is strongly associated with sensitive exposure to a range of conditions, including cirrhosis, fibrosis and ultimately, HCC. This review explores the intricate interplay between iron metabolism and HCC within the context of HBV infection. Hepatic iron overload can arise from liver injury and disruptions in iron homeostasis, causing hepatic necrosis, inflammation, and fibrosis, ultimately culminating in carcinogenesis. Moreover, alterations in serum iron components in HBV-related scenarios have been observed to impact the persistence of HBV infection. Notably, the progression of HBV-associated liver damage exhibits distinct characteristics at various stages of liver disease. In addition to elucidating the complex relationship between iron metabolism and HCC in the context of HBV infection, this review also investigates the prognostic implications of systemic iron levels for HCC. Furthermore, it aims to provide a comprehensive understanding of the intricate interplay between iron metabolism and HCC, extending the discussion to the context of hepatitis C virus (HCV) infection. By shedding light on these multifaceted connections, this review aims to contribute to our understanding of the pathogenesis of HBV-associated HCC and potentially identify novel therapeutic avenues for intervention.
(© 2024 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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