Radiation-Induced Macrovessel/Microvessel Disease.

Autor:	Abe JI; Department of Cardiology, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston (J.-I.A.)., Allen BG; Free Radical and Radiation Biology Program, Department of Radiation Oncology (B.G.A., K.A.M., I.M.G.), Carver College of Medicine, University of Iowa., Beyer AM; Department of Pharmacology and Physiology, Cardiovascular Center (A.M.B.), Medical College of Wisconsin, Milwaukee., Lewandowski D; Division of Cardiology/Cardiovascular Medicine, Department of Medicine (D.L.), Medical College of Wisconsin, Milwaukee., Mapuskar KA; Free Radical and Radiation Biology Program, Department of Radiation Oncology (B.G.A., K.A.M., I.M.G.), Carver College of Medicine, University of Iowa., Subramanian V; Department of Internal Medicine, Abboud Cardiovascular Research Center (V.S., M.R.T., I.M.G.), Carver College of Medicine, University of Iowa., Tamplin MR; Department of Internal Medicine, Abboud Cardiovascular Research Center (V.S., M.R.T., I.M.G.), Carver College of Medicine, University of Iowa., Grumbach IM; Free Radical and Radiation Biology Program, Department of Radiation Oncology (B.G.A., K.A.M., I.M.G.), Carver College of Medicine, University of Iowa.; Department of Internal Medicine, Abboud Cardiovascular Research Center (V.S., M.R.T., I.M.G.), Carver College of Medicine, University of Iowa.; Iowa City VA Healthcare System (I.M.G.).
Jazyk:	angličtina
Zdroj:	Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2024 Dec; Vol. 44 (12), pp. 2407-2415. Date of Electronic Publication: 2024 Oct 24.
DOI:	10.1161/ATVBAHA.124.319866
Abstrakt:	Radiation therapy (RT) is a cornerstone in cancer treatment (used in 50% of cases), yet challenges persist because damage to normal tissue through direct impact of radiation or bystander effects is inevitable. Injury of macrovessels by RT manifests as obstructive disease, which is akin to atherosclerotic disease. Historically observed in coronary arteries of patients treated for breast cancer and lymphoma, it also affects patients receiving contemporary therapy for lung and chest cancers. Moreover, radiation at various sites can lead to peripheral vascular disease. An aspect of radiation-induced injury that has received little attention is microvascular injury, which typically results from damage to the endothelium and is considered the primary driver of RT-induced toxicity in the skin, kidney, and brain. This review delves into the clinical manifestations of RT-induced vascular disease, signaling pathways, cellular targets affected by radiation injury, and preclinical models of RT-induced vascular injury. The goal is to inspire the development of innovative strategies to prevent RT-related cardiovascular disease. Competing Interests: None.
Databáze:	MEDLINE
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