Invasive Tracheobronchial Aspergillosis: A Fatal Complication in a Patient With Treated Mediastinal Lung Adenocarcinoma.

Autor:	Ikeda T; Department of Respiratory Medicine, Fukuoka University Hospital, Fukuoka, JPN., Yanagihara T; Department of Respiratory Medicine, Fukuoka University Hospital, Fukuoka, JPN., Chen M; Department of Respiratory Medicine, Fukuoka University Hospital, Fukuoka, JPN., Sanai R; Department of Respiratory Medicine, Fukuoka University Hospital, Fukuoka, JPN., Osaki Y; Department of Respiratory Medicine, Fukuoka University Hospital, Fukuoka, JPN., Kikushima M; Department of Pathology, Fukuoka University School of Medicine, Fukuoka, JPN., Aoki M; Department of Pathology, Fukuoka University School of Medicine, Fukuoka, JPN., Hamada Y; Department of Pathology, Fukuoka University School of Medicine, Fukuoka, JPN.; Pathology, Faculty of Medicine, Fukuoka University, Fukuoka, JPN., Hamasaki M; Department of Pathology, Fukuoka University School of Medicine, Fukuoka, JPN., Hamada N; Department of Respiratory Medicine, Fukuoka University Hospital, Fukuoka, JPN., Fujita M; Department of Respiratory Medicine, Fukuoka University School of Medicine, Fukuoka, JPN.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Sep 23; Vol. 16 (9), pp. e70024. Date of Electronic Publication: 2024 Sep 23 (Print Publication: 2024).
DOI:	10.7759/cureus.70024
Abstrakt:	Invasive tracheobronchial aspergillosis (ITBA) is a rare but severe form of invasive aspergillosis. This report presents a fatal case of ITBA in a 75-year-old man with a complex medical history including mediastinal lung adenocarcinoma, radiation pneumonitis, and pulmonary nocardiosis. The patient was admitted with worsening dyspnea and chest imaging revealed severe airway stenosis. Initially suspected to be cancer recurrence, post-mortem examination confirmed ITBA caused by Aspergillus penicillioides . Histopathological findings showed fungal invasion of the tracheobronchial tree with destruction, obstruction, and perforation of the airways. Multiple risk factors likely contributed to the development of ITBA in this patient, including diabetes, chronic obstructive pulmonary disease (COPD), long-term steroid use, prior COVID-19 infection, and a history of radiation therapy. This case highlights the diagnostic challenges of ITBA, particularly in patients with multiple comorbidities and a history of malignancy. It emphasizes the importance of considering fungal infections in the differential diagnosis of airway obstruction in high-risk patients. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Ikeda et al.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu