Topical Probiotics Reduce Atopic Dermatitis Severity: A Systematic Review and Meta-Analysis of Double-Blind, Randomized, Placebo-Controlled Trials.

Autor:	Flint E; Biomedical Sciences, University of Houston Tilman J. Fertitta Family College of Medicine, Houston, USA., Ahmad N; Biomedical Sciences, University of Houston Tilman J. Fertitta Family College of Medicine, Houston, USA., Rowland K; Biomedical Sciences, University of Houston Tilman J. Fertitta Family College of Medicine, Houston, USA., Hildebolt C; Anthropology, Washington University in St. Louis, St. Louis, USA., Raskin D; Biomedical Sciences, University of Houston Tilman J. Fertitta Family College of Medicine, Houston, USA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Sep 23; Vol. 16 (9), pp. e70001. Date of Electronic Publication: 2024 Sep 23 (Print Publication: 2024).
DOI:	10.7759/cureus.70001
Abstrakt:	Atopic dermatitis (AD) is a chronic skin disease that commonly appears during childhood but can present at any age. There are interventions that are effective in treating AD in children, but it has been difficult to find effective treatments for adults. This systematic review and meta-analysis sought to determine the efficacy of topical probiotic treatment for AD in adult populations. A database search was conducted of peer-reviewed, double-blind clinical trials, and studies underwent a systematic exclusion and inclusion process, yielding four that met the criteria. Disease severity, as measured by a standardized scoring tool SCORAD (SCORing Atopic Dermatitis), was culled from each study and compared to placebo at two-week and four-week time points. All studies showed improvement in SCORAD in the treatment groups compared to baseline at all time points. Two showed significant decreases in SCORAD after two weeks of treatment, and three studies showed long-lasting improvement after four weeks of treatment. Interestingly, while each study showed a reduction in the severity of AD at the two- and four-week time points, a pooled meta-analysis did not show a statistically significant difference between treatment and control at four weeks of treatment. Clinically, there may be benefits to topical probiotic usage as evidenced by the individual studies; more studies need to be performed including adults to show statistical significance. Competing Interests: Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Flint et al.)
Databáze:	MEDLINE
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