Use of Cell-Free DNA Testing to Diagnose Infective Endocarditis in a Patient With Negative Blood Cultures.

Autor:	Hennis R; Internal Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, USA., Raynor MA; Internal Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, USA., Hock RA; Internal Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, USA., Yousaf M; Internal Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, USA., Allen JC; Internal Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, USA., Heh E; Internal Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, USA., Bies JJ; Internal Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, USA., Meza A; Division of Infectious Diseases, Texas Tech University Health Sciences Center El Paso, El Paso, USA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Oct 23; Vol. 16 (10), pp. e72191. Date of Electronic Publication: 2024 Oct 23 (Print Publication: 2024).
DOI:	10.7759/cureus.72191
Abstrakt:	Infective endocarditis (IE) is associated with significant morbidity and mortality. Its diagnosis can be especially challenging, as can the identification of a causative pathogen, which, in turn, is crucial for appropriate management. Here, we present a rare case of Streptococcus intermedius endocarditis complicated by lung and cerebral abscess in which clinicians employed cell-free deoxyribonucleic acid (cfDNA) testing to confirm the diagnosis, establish a causative pathogen, and determine appropriate antibiotic therapy. Notably, the positive cfDNA test prevented the need for brain biopsy in this case and has implications for diagnostic and therapeutic guidelines. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Hennis et al.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu