The chemoprotective hormetic effects of rosmarinic acid.
| Autor: | Calabrese EJ; School of Public Health and Health Sciences, Department of Environmental Health Sciences, Morrill I-N344, University of Massachusetts, Amherst, MA, 01003, United States of America., Pressman P; University of Maine, Orono, ME, 04469, United States of America., Hayes AW; Center for Environmental Occupational Risk Analysis and Management, College of Public Health, University of South Florida, Tampa, FL, United States of America., Dhawan G; Sri Guru Ram Das (SGRD), University of Health Sciences, Amritsar, India., Kapoor R; Saint Francis Hospital and Medical Center, Hartford, CT, United States of America., Agathokleous E; School of Ecology and Applied Meteorology, Nanjing University of Information Science & Technology, Nanjing, 210044, China., Baldwin LA; 5 Sapphire Lane, Greenfield, MA, 01301, United States of America., Calabrese V; Department of Biomedical and Biotechnological Sciences, School of Medicine University of Catania, Catania, 95123, Italy. |
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| Jazyk: | angličtina |
| Zdroj: | Open medicine (Warsaw, Poland) [Open Med (Wars)] 2024 Oct 21; Vol. 19 (1), pp. 20241065. Date of Electronic Publication: 2024 Oct 21 (Print Publication: 2024). |
| DOI: | 10.1515/med-2024-1065 |
| Abstrakt: | Rosmarinic acid is a polyphenol found in numerous fruits and vegetables, consumed in supplement form, and tested in numerous clinical trials for therapeutic applications due to its putative chemopreventive properties. Rosmarinic acid has been extensively studied at the cellular, whole animal, and molecular mechanism levels, presenting a complex array of multi-system biological effects. Rosmarinic acid-induced hormetic dose responses are widespread, occurring in numerous biological models and cell types for a broad range of endpoints. Consequently, this article provides the first assessment of rosmarinic acid-induced hormetic concentration/dose responses, their quantitative features, mechanistic foundations, extrapolative strengths/limitations, and their biomedical, clinical, and public health implications. Competing Interests: Conflict of interest: The authors declare no competing interests. However, Vittorio Calabrese serves as Editor-in-Chief in Open Medicine, but this fact has not influenced the peer-review process. (© 2024 the author(s), published by De Gruyter.) |
| Databáze: | MEDLINE |
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