Computed tomography features in prediction of histological differentiation of pancreatic neuroendocrine neoplasms - a single-centre retrospective cohort study.

Autor:	Herzyk JK; Students' Scientific Society, Department of Radiology & Nuclear Medicine, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland., Majewska K; Department of Digestive Tract Surgery, Medical University of Silesia, Katowice, Poland., Jakimów K; Students' Scientific Society, Department of Radiology & Nuclear Medicine, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland., Ciesielka J; Students' Scientific Society, Department of Radiology & Nuclear Medicine, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland., Pilch-Kowalczyk J; Department of Radiology & Nuclear Medicine, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland.
Jazyk:	angličtina
Zdroj:	Polish journal of radiology [Pol J Radiol] 2024 Sep 30; Vol. 89, pp. e457-e463. Date of Electronic Publication: 2024 Sep 30 (Print Publication: 2024).
DOI:	10.5114/pjr/191838
Abstrakt:	Purpose: The aim of our study was to analyse the histological differentiation and computed tomography imaging features of pancreatic neuroendocrine neoplasms (PNENs). Material and Methods: We performed a retrospective single-centre cohort study of 157 patients with histologically confirmed PNEN. We compared the results of the preoperative biopsy from the tumour with reports of the multi-slice computed tomography performed by a radiologist with 30 years of clinical practice. Results: Specific computed tomography (CT) features are associated with histological differentiation, such as enhancement in the arterial phase ( p = 0.032), Wirsung's duct dilatation ( p = 0.001), other organ infiltration ( p < 0.001), distant metastases ( p < 0.001), and enlarged regional lymph nodes ( p = 0.018). When there is an organ infiltration, the likelihood of the tumour having histological malignancy grades G2 or G3 triples (95% CI: 1.21-8.06). Likewise, the existence of distant metastases increases the risk almost fourfold (95% CI: 1.44-10.61), and a tumour size of 2 cm or larger is linked to a nearly threefold rise in the risk of histological malignancy grades G2 or G3 (95% CI: 1.21-6.24). Conclusions: Certain CT characteristics: enhancement during the arterial phase, Wirsung's duct dilatation, organ infiltration, distant metastases, and the enlargement of regional lymph nodes are linked to histological differentiation. Competing Interests: 1. Institutional review board statement: Not applicable. 2. Assistance with the article: None. 3. Financial support and sponsorship: None. 4. Conflicts of interest: None. (© Pol J Radiol 2024.)
Databáze:	MEDLINE
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