Synthesis and characterization of activated carbon-supported magnetic nanocomposite (MNPs-OLAC) obtained from okra leaves as a nanocarrier for targeted delivery of morin hydrate.

Autor:	Öziç C; Department of Basic Medical Sciences, Department of Medical Biology, Kafkas University, Faculty of Medicine, Kars, Türkiye., Ertaş E; Department of Food Technology, Vocational School of Technical Sciences, Batman University, Batman, Türkiye., Baran MF; Department of Food Technology, Vocational School of Technical Sciences, Batman University, Batman, Türkiye., Baran A; Department of Biology, Graduate Education Institute, Mardin Artuklu University, Mardin, Türkiye., Ahmadian E; Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Eftekhari A; Department of Biochemistry, Faculty of Science, Ege University, Izmir, Türkiye.; Department of Life Sciences, Western Caspian University, Baku, Azerbaijan., Khalilov R; Department of Biophysics and Biochemistry, Baku State University, Baku, Azerbaijan., Aliyev E; Department of Biology and Ecology, Lankaran State University, Lankaran, Azerbaijan., Yıldıztekin M; Department of Herbal and Animal Production, Koycegiz Vocational School, Mugla Sıtkı Kocman University, Mugla, Türkiye.
Jazyk:	angličtina
Zdroj:	Frontiers in pharmacology [Front Pharmacol] 2024 Oct 09; Vol. 15, pp. 1482130. Date of Electronic Publication: 2024 Oct 09 (Print Publication: 2024).
DOI:	10.3389/fphar.2024.1482130
Abstrakt:	Introduction: The method of encapsulating the drug molecule in a carrier, such as a magnetic nanoparticle, is a promising development that has the potential to deliver the medicine to the site where it is intended to be administered. Morin is a pentahydroxyflavone obtained from the leaves, stems, and fruits of various plantsmainly from the Moraceae family exhibiting diverse pharmacological activities such as anti-inflammatory, anti-oxidant, and free radical scavenging and helps treat diseases such as diabetes, myocardial infarction and cancer. Methods: In this study, we conducted the synthesis of a nanocomposite with magnetic properties by coating biocompatible activated carbon obtained from okra plant leaves with magnetic nanoparticles. Results: Characterization of the synthesized activated carbon-coated magnetic nanocomposite was confirmed by Fourier transform infrared, scanning electron microscopy, dynamic light scattering, and zeta potential. The cytotoxic effects of the drug-loaded magnetic nanocomposite were examined in HT-29 (Colorectal), MCF-7 (breast), U373 (brain), T98-G (Glioblastoma) cancer cell lines, and human umbilical vein endothelial cells healthy cell line. Discussion: We studied the loading and release behavior of morin hydrate in the activated carbon-coated magnetic nanocomposite. Activated carbon-coated magnetic nanocomposite carriers can show promising results for the delivery of Morin hydrate drugs to the targeted site. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Öziç, Ertaş, Baran, Baran, Ahmadian, Eftekhari, Khalilov, Aliyev and Yıldıztekin.)
Databáze:	MEDLINE
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