A biopsy-based Immunoscore in patients with treatment-naïve resectable gastric cancer.
| Autor: | Soeratram TTD; Department of Pathology, Amsterdam UMC location VUmc, Amsterdam, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Cancer Center Amsterdam, Cancer Biology and Immunology, Amsterdam, The Netherlands., Beentjes I; Department of Pathology, Amsterdam UMC location VUmc, Amsterdam, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Cancer Center Amsterdam, Cancer Biology and Immunology, Amsterdam, The Netherlands., Egthuijsen JMP; Department of Pathology, Amsterdam UMC location VUmc, Amsterdam, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Cancer Center Amsterdam, Cancer Biology and Immunology, Amsterdam, The Netherlands., Mookhoek A; Institute of Tissue Medicine and Pathology, University of Bern, Bern, Switzerland., Lange MM; Department of Pathology, Amsterdam UMC location VUmc Amsterdam, Amsterdam, The Netherlands., Meershoek-Klein Kranenbarg E; Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands., Hartgrink HH; Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands., van de Velde CJH; Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands., Ylstra B; Department of Pathology, Amsterdam UMC location VUmc, Amsterdam, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Cancer Center Amsterdam, Cancer Biology and Immunology, Amsterdam, The Netherlands., van Laarhoven HWM; Cancer Center Amsterdam, Cancer Biology and Immunology, Amsterdam, The Netherlands.; Department of Medical Oncology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands., van Grieken NCT; Department of Pathology, Amsterdam UMC location VUmc, Amsterdam, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.; Cancer Center Amsterdam, Cancer Biology and Immunology, Amsterdam, The Netherlands. |
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| Jazyk: | angličtina |
| Zdroj: | Therapeutic advances in medical oncology [Ther Adv Med Oncol] 2024 Oct 21; Vol. 16, pp. 17588359241287747. Date of Electronic Publication: 2024 Oct 21 (Print Publication: 2024). |
| DOI: | 10.1177/17588359241287747 |
| Abstrakt: | Background: The prognostic significance of T-cell densities in gastric cancer (GC) was previously demonstrated in surgical resection specimens. For prognosis or response prediction, it is preferable to identify biomarkers in pre-treatment biopsies; yet, its representativeness of the tumor immune microenvironment is unclear. Objectives: This study aimed to evaluate the concordance and prognostic value of T-cell densities in paired biopsies and resections. Methods: Paired diagnostic biopsies and surgical resections were available for 131 patients with resectable GC who were treated with surgery alone in the D1/D2 trial. T-cell markers such as CD3, CD45RO, CD8, FOXP3, and Granzyme B were assessed by immunohistochemistry and digitally quantified. Tumors were categorized into high and low subgroups for each marker. The concordance between biopsies and resections was determined for each marker with Cohen's κ. To determine the prognostic value of T cells in biopsies, Cox regression was performed. Results: The concordance of T-cell high and low tumors was moderate for CD8 (κ = 0.58) and weak for other markers (κ < 0.3). CD8 and FOXP3 densities in biopsies were significantly associated with cancer-specific survival. Multivariable analysis showed that an Immunoscore incorporating CD8 and FOXP3 served as an independent prognostic marker (low vs high: hazard ratio 3.40, 95% confidence interval: 1.27-9.10; p = 0.015). Conclusion: Although the concordance in T-cell densities between biopsy and resection specimens is modest, a biopsy-based Immunoscore identified distinct biological subgroups with prognostic potential. To fully evaluate the prognostic performance of this biopsy Immunoscore, additional studies are warranted. Competing Interests: The authors declare that there is no conflict of interest. (© The Author(s), 2024.) |
| Databáze: | MEDLINE |
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