Synthetic Periodontal Guided Tissue Regeneration Membrane with Self-Assembling Biphasic Structure and Temperature-Sensitive Shape Maintenance.

Autor: Swanson WB; Department of Biologic and Materials Science, School of Dentistry, University of Michigan, Ann Arbor, MI, 48109, USA., Woodbury SM; Department of Biologic and Materials Science, School of Dentistry, University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Chemistry, College of Literature, Science and the Arts, University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Physics, College of Literature, Science and the Arts, University of Michigan, Ann Arbor, MI, 48109, USA., Dal-Fabbro R; Department of Cariology, Restorative Sciences and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, 48109, USA., Douglas L; Department of Chemistry, College of Literature, Science and the Arts, University of Michigan, Ann Arbor, MI, 48109, USA., Albright J; Department of Biomedical Engineering, College of Engineering, University of Michigan, Ann Arbor, MI, 48109, USA., Eberle M; Department of Chemistry, College of Literature, Science and the Arts, University of Michigan, Ann Arbor, MI, 48109, USA., Niemann D; Department of Chemistry, College of Literature, Science and the Arts, University of Michigan, Ann Arbor, MI, 48109, USA., Xu J; Department of Cariology, Restorative Sciences and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, 48109, USA., Bottino MC; Department of Cariology, Restorative Sciences and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Biomedical Engineering, College of Engineering, University of Michigan, Ann Arbor, MI, 48109, USA., Mishina Y; Department of Biologic and Materials Science, School of Dentistry, University of Michigan, Ann Arbor, MI, 48109, USA.
Jazyk: angličtina
Zdroj: Advanced healthcare materials [Adv Healthc Mater] 2024 Oct 23, pp. e2402137. Date of Electronic Publication: 2024 Oct 23.
DOI: 10.1002/adhm.202402137
Abstrakt: Periodontal disease poses significant challenges to the long-term stability of oral health by destroying the supporting structures of teeth. Guided tissue regeneration techniques, particularly barrier membranes, enable local regeneration by providing an isolated, protected compartment for osseous wound healing while excluding epithelial tissue. Here, this study reports on a thermosensitive periodontal membrane (TSPM) technology designed to overcome the mechanical limitations of current membranes through a semi-interpenetrating network of high molecular weight poly(L-lactic acid) (PLLA) and in situ-polymerized mesh of poly(ε-caprolactone)diacrylate (PCL-DA), and poly lactide-co-glycolide diacrylate (PLGA-DA). An optimized composition allows facile reshaping at greater than 52 °C and rigid shape maintenance at physiological temperature. Its unique bilayer morphology is achieved through self-assembly and thermally-induced phase separation, resulting in distinct yet continuous smooth and nanofibrous compartments adequate for epithelial occlusion and regeneration. Incorporating PLGA-DA enhances the membrane's hydrophilicity and degradation properties, facilitating a more rapid and controlled degradation and therapeutic delivery. This study demonstrates its ability to promote local regeneration by serving as a barrier membrane and simultaneously as a scaffolding matrix in a rat orthotopic periodontal defect model. The TSPM outperformed a clinically available material (Epi-Guide) to facilitate robust alveolar bone and periodontal ligament regeneration at 4 and 8 weeks.
(© 2024 The Author(s). Advanced Healthcare Materials published by Wiley‐VCH GmbH.)
Databáze: MEDLINE
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