Infectious etiology of intussusception in Indian children less than 2 years old: a matched case-control analysis.

Autor: Praharaj I; The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu, India.; ICMR Regional Medical Research Centre, Bhubaneswar, Odisha, India., Reddy SN; The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu, India., Nair NP; The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu, India., Tate JE; Centers for Disease Control and Prevention, Atlanta, GA, USA., Giri S; The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu, India.; ICMR Regional Medical Research Centre, Bhubaneswar, Odisha, India., Thiyagarajan V; The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu, India., Mohan VR; Department of Community Health, Christian Medical College, Vellore, Tamil Nadu, India., Revathi R; The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu, India., Maheshwari K; The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu, India., Hemavathy P; The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu, India., Kumar N; The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu, India., Gupte MD; Translational Health Science and Technology Institute, Faridabad, India., Arora R; Translational Health Science and Technology Institute, Faridabad, India., Senthamizh S; The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu, India., Mekala S; Kurnool Medical College and Government General Hospital, Kurnool, Andhra Pradesh, India., Goru KB; Government General Hospital and Rangaraya Medical College, Kakinada, Andhra Pradesh, India., Pamu P; King George Hospital and Andhra Medical College, Visakhapatnam, Andhra Pradesh, India., Badur M; Sri Venkateshwara Medical College, Tirupati, Andhra Pradesh, India., Pradhan S; Sardar Vallabh Bhai Patel Post Graduate Institute of Paediatrics, Cuttack, Odisha, India., Dash M; Institute of Medical Sciences, SUM Hospital, Bhubaneswar, Odisha, India., Mohakud NK; Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, India., Ray RK; Hi-Tech Hospital, Bhubaneswar, Odisha, India., Gathwala G; Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India., Gupta M; Post Graduate Institute of Medical Education and Research, Chandigarh, India., Kanojia R; Post Graduate Institute of Medical Education and Research, Chandigarh, India., Gupta R; Sawai Man Singh Medical College, Jaipur, Rajasthan, India., Goyal S; Rabindranath Tagore Medical College, Udaipur, Rajasthan, India., Sharma P; Dr. Sampurnanand Medical College, Jodhpur, Rajasthan, India., Mathew MA; Malankara Orthodox Syrian Church Medical College Hospital, Kolencherry, Kerala, India., Kochukaleekal Jacob TJ; Department of Pediatric Surgery, Christian Medical College, Vellore, Tamil Nadu, India., Sundaram B; Kanchi Kamakoti Child Trust Hospital, Chennai, Tamil Nadu, India., Girish Kumar CP; National Institute of Epidemiology, Chennai, Tamil Nadu, India., Dorairaj P; Institute of Child Health, Chennai, Tamil Nadu, India., Pitchumani R; Government Rajaji Hospital and Madurai Medical College, Madurai, Tamil Nadu, India., Maniam R; Coimbatore Medical College, Coimbatore, Tamil Nadu, India., Kumaravel S; Jawaharlal Nehru Institute of Post-graduate Medical Education & Research, Puducherry, India., Jain H; Mahatma Gandhi Memorial Medical College, Indore, Madhya Pradesh, India., Goswami JK; Government Medical College, Guwahati, Assam, India., Wakhlu A; King George Medical College, Lucknow, Uttar Pradesh, India., Gupta V; Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India., Liu J; Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, USA., Houpt ER; Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, USA., Parashar UD; The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu, India., Kang G; The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu, India. gkang@cmcvellore.ac.in.
Jazyk: angličtina
Zdroj: Gut pathogens [Gut Pathog] 2024 Oct 23; Vol. 16 (1), pp. 61. Date of Electronic Publication: 2024 Oct 23.
DOI: 10.1186/s13099-024-00659-z
Abstrakt: Background: Enteric infections are hypothesized to be associated with intussusception in children. A small increase in intussusception following rotavirus vaccination has been seen in some settings. We conducted post-marketing surveillance for intussusception following rotavirus vaccine, Rotavac introduction in India and evaluated association of intussusception with enteric pathogens.
Methods: In a case-control study nested within a large sentinel hospital-based surveillance program in India, stool samples from 272 children aged less than 2 years admitted for intussusception and 272 age-, gender- and location-matched controls were evaluated with Taqman array card based molecular assays to detect enteric viruses, bacterial enteropathogens and parasites. Matched case-control analysis with conditional logistic regression evaluated association of enteropathogens with intussusception. Population attributable fractions (PAF) were calculated for enteropathogens significantly associated with intussusception.
Results: The most prevalent enteropathogens in cases and controls were enteroaggregative Escherichia coli, adenovirus 40/41, adenovirus C serotypes and enteroviruses. Children with intussusception were more likely to harbor adenovirus C serotypes (adjusted odds-ratio (aOR) = 1.74; 95% confidence interval (CI) 1.06-2.87) and enteroviruses (aOR = 1.77; 95% CI 1.05-2.97) than controls. Rotavirus was not associated with increased intussusception risk. Adenovirus C (PAF = 16.9%; 95% CI 4.7% - 27.6%) and enteroviruses (PAF = 14.7%; 95% CI 4.2% - 24.1%) had the highest population attributable fraction for intussusception.
Conclusion: Adenovirus C serotypes and enteroviruses were significantly associated with intussusception in Indian children. Rotavirus was not associated with risk of intussusception.
(© 2024. The Author(s).)
Databáze: MEDLINE
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