Sensory experience steers representational drift in mouse visual cortex.

Autor: Bauer J; Max Planck Institute for Biological Intelligence, Martinsried, Germany. joel.bauer@ucl.ac.uk.; International Max Planck Research School for Molecular Life Sciences, Martinsried, Germany. joel.bauer@ucl.ac.uk.; Sainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, London, UK. joel.bauer@ucl.ac.uk., Lewin U; Max Planck Institute for Biological Intelligence, Martinsried, Germany.; Graduate School of Systemic Neurosciences, Ludwig-Maximilians-Universität München, Planegg, Germany., Herbert E; School of Life Sciences, Technical University of Munich, Freising, Germany., Gjorgjieva J; School of Life Sciences, Technical University of Munich, Freising, Germany., Schoonover CE; Mortimer B. Zuckerman Mind Brain Behavior Institute, Department of Neuroscience, Columbia University, New York, NY, USA.; Allen Institute for Neural Dynamics, Seattle, WA, USA., Fink AJP; Mortimer B. Zuckerman Mind Brain Behavior Institute, Department of Neuroscience, Columbia University, New York, NY, USA.; Department of Neurobiology, Northwestern University, Evanston, IL, USA., Rose T; Max Planck Institute for Biological Intelligence, Martinsried, Germany.; Institute for Experimental Epileptology and Cognition Research, University of Bonn, Medical Center, Bonn, Germany., Bonhoeffer T; Max Planck Institute for Biological Intelligence, Martinsried, Germany., Hübener M; Max Planck Institute for Biological Intelligence, Martinsried, Germany. mark.huebener@bi.mpg.de.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 Oct 23; Vol. 15 (1), pp. 9153. Date of Electronic Publication: 2024 Oct 23.
DOI: 10.1038/s41467-024-53326-x
Abstrakt: Representational drift-the gradual continuous change of neuronal representations-has been observed across many brain areas. It is unclear whether drift is caused by synaptic plasticity elicited by sensory experience, or by the intrinsic volatility of synapses. Here, using chronic two-photon calcium imaging in primary visual cortex of female mice, we find that the preferred stimulus orientation of individual neurons slowly drifts over the course of weeks. By using cylinder lens goggles to limit visual experience to a narrow range of orientations, we show that the direction of drift, but not its magnitude, is biased by the statistics of visual input. A network model suggests that drift of preferred orientation largely results from synaptic volatility, which under normal visual conditions is counteracted by experience-driven Hebbian mechanisms, stabilizing preferred orientation. Under deprivation conditions these Hebbian mechanisms enable adaptation. Thus, Hebbian synaptic plasticity steers drift to match the statistics of the environment.
(© 2024. The Author(s).)
Databáze: MEDLINE
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