Unveiling the hippocampal subfield changes across the Alzheimer's disease continuum: a systematic review of neuroimaging studies.

Autor: Zilioli A; Department of Medicine and Surgery, Unit of Neurology, University of Parma, Via Gramsci 14, 43126, Parma, Italy., Pancaldi B; Department of Medicine and Surgery, Unit of Neurology, University of Parma, Via Gramsci 14, 43126, Parma, Italy., Baumeister H; German Center for Neurodegenerative Diseases (DZNE), Leipziger Str. 44, 39120, Magdeburg, Germany., Busi G; Department of Medicine and Surgery, Unit of Neurology, University of Parma, Via Gramsci 14, 43126, Parma, Italy., Misirocchi F; Department of Medicine and Surgery, Unit of Neurology, University of Parma, Via Gramsci 14, 43126, Parma, Italy. Francesco.misirocchi@unipr.it., Mutti C; Department of Medicine and Surgery, Unit of Neurology, University-Hospital of Parma, Parma, Italy.; Sleep Disorders Center, Department of Medicine and Surgery, University of Parma, Parma, Italy., Florindo I; Department of Medicine and Surgery, Unit of Neurology, University-Hospital of Parma, Parma, Italy., Morelli N; Department of Neurology, G. da Saliceto Hospital, Piacenza, Italy., Mohanty R; Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Blickagången 16 (NEO building, floor 7th), 14152, Huddinge, Stockholm, Sweden., Berron D; German Center for Neurodegenerative Diseases (DZNE), Leipziger Str. 44, 39120, Magdeburg, Germany.; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden., Westman E; Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Blickagången 16 (NEO building, floor 7th), 14152, Huddinge, Stockholm, Sweden.; Department of Neuroimaging, Center for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Spallazzi M; Department of Medicine and Surgery, Unit of Neurology, University-Hospital of Parma, Parma, Italy.
Jazyk: angličtina
Zdroj: Brain imaging and behavior [Brain Imaging Behav] 2024 Oct 23. Date of Electronic Publication: 2024 Oct 23.
DOI: 10.1007/s11682-024-00952-0
Abstrakt: Studies exploring the hippocampal subfield atrophy in Alzheimer's disease (AD) have shown contradictory results. This review aims to disentangle such heterogeneity by investigating the dynamic changes of hippocampal subfields across the AD continuum. We systematically searched the PubMed and EMBASE databases for case-control studies. Selected studies included investigations of biomarker-based amyloid status and reported data on hippocampal subfield atrophy using advanced MRI techniques. Twelve studies were included. Despite high heterogeneity, a distinguishable pattern of vulnerability of hippocampal subfields can be recognized from the cognitively unimpaired phase to the dementia stage, shedding light on hippocampal changes with disease progression. Consistent findings revealed atrophy in the subiculum and presubiculum, along with a potential increase in volume in the cornu ammonis (CA) among the cognitively unimpaired group, a feature not observed in patients experiencing subjective cognitive decline. Atrophy in the subiculum, presubiculum, CA 1-4, and the dentate gyrus characterized the mild cognitive impairment stage, with a more pronounced severity in the progression to dementia.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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