Mechanisms suppressing noncoding translation.

Autor: Kesner JS; Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA., Wu X; Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address: xuebing.wu@columbia.edu.
Jazyk: angličtina
Zdroj: Trends in cell biology [Trends Cell Biol] 2024 Oct 22. Date of Electronic Publication: 2024 Oct 22.
DOI: 10.1016/j.tcb.2024.09.004
Abstrakt: The majority of the DNA sequence in our genome is noncoding and not intended for synthesizing proteins. Nonetheless, genome-wide mapping of ribosome footprints has revealed widespread translation in annotated noncoding sequences, including long noncoding RNAs (lncRNAs), untranslated regions (UTRs), and introns of mRNAs. How cells suppress the translation of potentially toxic proteins from various noncoding sequences remains poorly understood. This review summarizes mechanisms for the mitigation of noncoding translation, including the BCL2-associated athanogene 6 (BAG6)-mediated proteasomal degradation pathway, which has emerged as a unifying mechanism to suppress the translation of diverse noncoding sequences in metazoan cells.
Competing Interests: Declaration of interests X.W. is a member of the Scientific Advisory Board for Epitor Therapeutics. The remaining author has no interests to declare.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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