Systems immunology insights into brain metastasis.

Autor: Dong W; Department of Systems Medicine and Bioengineering and T. T. and W. F. Chao Center for BRAIN, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Weill Cornell Medicine, Houston, TX 77030, USA., Sheng J; Department of Systems Medicine and Bioengineering and T. T. and W. F. Chao Center for BRAIN, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Weill Cornell Medicine, Houston, TX 77030, USA., Cui JZM; Department of Systems Medicine and Bioengineering and T. T. and W. F. Chao Center for BRAIN, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Weill Cornell Medicine, Houston, TX 77030, USA., Zhao H; Department of Systems Medicine and Bioengineering and T. T. and W. F. Chao Center for BRAIN, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Weill Cornell Medicine, Houston, TX 77030, USA. Electronic address: hzhao@houstonmehtodist.org., Wong STC; Department of Systems Medicine and Bioengineering and T. T. and W. F. Chao Center for BRAIN, Houston Methodist Neal Cancer Center, Houston Methodist Hospital, Weill Cornell Medicine, Houston, TX 77030, USA. Electronic address: stwong@houstonmethodist.org.
Jazyk: angličtina
Zdroj: Trends in immunology [Trends Immunol] 2024 Nov; Vol. 45 (11), pp. 903-916. Date of Electronic Publication: 2024 Oct 22.
DOI: 10.1016/j.it.2024.09.010
Abstrakt: Brain metastasis poses formidable clinical challenges due to its intricate interactions with the brain's unique immune environment, often resulting in poor prognoses. This review delves into systems immunology's role in uncovering the dynamic interplay between metastatic cancer cells and brain immunity. Leveraging spatial and single-cell technologies, along with advanced computational modeling, systems immunology offers unprecedented insights into mechanisms of immune evasion and tumor proliferation. Recent studies highlight potential immunotherapeutic targets, suggesting strategies to boost antitumor immunity and counteract cancer cell evasion in the brain. Despite substantial progress, challenges persist, particularly in accurately simulating human conditions. This review underscores the need for interdisciplinary collaboration to harness systems immunology's full potential, aiming to dramatically improve outcomes for patients with brain metastasis.
Competing Interests: Declaration of interests All the authors declare they have no conflict of interest.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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