Lentigo Maligna Part I: Epidemiology, Risk Factors, and Diagnosis.

Autor: Gupta S; Massachusetts Eye and Ear, Boston, MA 02114, USA., Shaughnessy M; Department of Dermatology, Massachusetts General Hospital, Boston, MA 02114, USA., Rashid S; Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Stagner AM; Massachusetts Eye and Ear, Boston, MA 02114, USA., Fewkes J; Massachusetts Eye and Ear, Boston, MA 02114, USA; Department of Dermatology, Massachusetts General Hospital, Boston, MA 02114, USA., Marghoob AA; Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA., Tsao H; Department of Dermatology, Massachusetts General Hospital, Boston, MA 02114, USA; Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address: HTsao@mgh.harvard.edu.
Jazyk: angličtina
Zdroj: Journal of the American Academy of Dermatology [J Am Acad Dermatol] 2024 Oct 21. Date of Electronic Publication: 2024 Oct 21.
DOI: 10.1016/j.jaad.2024.09.065
Abstrakt: Lentigo maligna (LM) is an increasingly common subtype of melanoma, presenting as a slow-growing tan-brown macule or patch with irregular borders arising on chronically solar-damaged skin. This two-part continuing medical education (CME) series provides an overview of LM. Part I reviews LM's epidemiology, risk factors, and clinical presentation. Clinical tools to aid in diagnosis - such as dermoscopy and reflectance confocal microscopy - are discussed, as well as optimal biopsy strategies. Histopathology and current understanding of molecular underpinnings are also reviewed. Management of LM presents unique challenges given a predilection for subclinical spread on functionally and cosmetically sensitive areas such as the face. Part II reviews the two pillars of management including both surgical and non-surgical treatment options and surveillance.
(Copyright © 2024. Published by Elsevier Inc.)
Databáze: MEDLINE
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