Photodynamic therapy: An emerging therapeutic modality in dentistry.

Autor: Suresh N; Department of Oral and Maxillofacial Diseases, Helsinki University and University Hospital, Helsinki, Finland; Pushpagiri Institute of Medical Sciences and Research Centre, Mendicity, Perumthuruthy, Tiruvalla, Kerala, India. Electronic address: nandita.suresh@helsinki.fi., Joseph B; Department of Oral and Maxillofacial Diseases, Helsinki University and University Hospital, Helsinki, Finland; Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, India., Sathyan P; Department of Oral Pathology, Government Dental College, Kottayam, Kerala, India., Sweety VK; Pushpagiri Institute of Medical Sciences and Research Centre, Mendicity, Perumthuruthy, Tiruvalla, Kerala, India., Waltimo T; Department of Oral and Maxillofacial Diseases, Helsinki University and University Hospital, Helsinki, Finland; Faculty of Medicine, University of Basel, Basel, Switzerland., Anil S; Oral Health Institute, Hamad Medical Corporation, Doha, Qatar; College of Dental Medicine, Qatar University, Doha, Qatar.
Jazyk: angličtina
Zdroj: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2024 Nov 15; Vol. 114, pp. 117962. Date of Electronic Publication: 2024 Oct 19.
DOI: 10.1016/j.bmc.2024.117962
Abstrakt: Photodynamic Therapy (PDT) is a rapidly evolving, non-invasive treatment modality with considerable promise in dental pharmacotherapeutics. This review article comprehensively examines PDT, beginning with its principles and then delving into its diverse applications in dentistry, including periodontal disease, endodontics, oral cancer, dental implants, and dental caries. Each area presents the latest research and discusses the potential benefits and challenges. The unique advantages of PDT are highlighted, such as selective targeting, broad-spectrum antimicrobial effect, lack of resistance development, and its synergistic effect with other treatments. However, challenges such as photosensitizer delivery, light penetration, oxygen availability, and the need to standardize protocols are also acknowledged. The review further explores future perspectives of PDT in dentistry, including advancements in photosensitizer design, overcoming hypoxic limitations, personalized protocols, integration with other therapies, and standardization and regulation. The potential of advanced technologies, such as nanotechnology and synthetic biology, to improve PDT outcomes is also discussed. The review concludes that while PDT has shown immense potential to revolutionize dental pharmacotherapeutics, further high-quality research is needed to translate this potential into everyday dental practice. The promising future of PDT in dentistry suggests a more effective and less invasive treatment option for a range of dental conditions.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: