Intravenous versus oral tranexamic acid in elderly transforaminal lumbar interbody fusion patients: A prospective cohort study.

Autor: Li X; Department of Orthopedics, The Affiliated Lianyungang Hospital of Xuzhou Medical University, 6 Zhenhua East Rd, Lianyungang 221000, China., Yin Y; Department of Orthopedics, The Affiliated Lianyungang Hospital of Xuzhou Medical University, 6 Zhenhua East Rd, Lianyungang 221000, China., Wen M; Department of Orthopedics, The First People's Hospital Of Lianyungang, 6 Zhenhua East Rd, Lianyungang 221000, China., Lu X; Department of Orthopedics, The First People's Hospital Of Lianyungang, 6 Zhenhua East Rd, Lianyungang 221000, China., Qin RJ; Department of Orthopedics, The Affiliated Lianyungang Hospital of Xuzhou Medical University, 6 Zhenhua East Rd, Lianyungang 221000, China. Electronic address: lyg2240012@163.com., Lv Y; Department of Orthopedics, Lianyungang Clinical College of Nanjing Medical University, 6 Zhenhua East Rd, Lianyungang 221000, China. Electronic address: gwykr@outlook.com.
Jazyk: angličtina
Zdroj: Clinical neurology and neurosurgery [Clin Neurol Neurosurg] 2024 Nov; Vol. 246, pp. 108607. Date of Electronic Publication: 2024 Oct 21.
DOI: 10.1016/j.clineuro.2024.108607
Abstrakt: Background: Tranexamic acid (TXA) can effectively reduce intraoperative blood loss and transfusion rates. However, in spinal surgery, the number of surgical levels can significantly influence intraoperative and postoperative bleeding, particularly among the elderly, contributing to the persistently high rate of transfusion during the perioperative period. To verify the safety and efficacy of different application methods of TXA in elderly patients undergoing transforaminal lumbar interbody fusion (TLIF), a prospective cohort study was conducted.
Methods: A total of 958 patients undergoing TLIF were randomly assigned to receive 2 g of oral TXA two hours before surgery or 15 mg/kg of intravenous TXA 30 min before surgery, or to a control group. The samples were further divided into three categories based on the number of fused segments (one-level fusion, two-level fusion, and three-level fusion). The primary outcomes were the total blood loss and transfusion rate. Secondary outcomes included intraoperative blood loss, postoperative blood loss, drainage volume, time until drain removal, perioperative transfusion volume, length of stay, thrombotic events, and other adverse events.
Results: 336 patients received intravenous TXA and 314 patients were received oral TXA. Patient demographic factors were similar between groups. In the one-level fusion surgery cohort, comparisons across the three groups revealed no statistically significant disparities in total blood loss, transfusion rates, or drainage volumes (P > 0.05). In both two-level and three-level fusion surgeries, patients administered with TXA experienced a notably reduced perioperative bleeding compared to the control group (P < 0.01). Interestingly, a significant disparity was observed in the drainage volumes between the intravenous and oral administration groups (P = 0.026), specifically within the context of two and three-level fusion procedures.
Conclusion: In elderly patients undergoing TLIF surgery, both intravenous and oral administrations of TXA are safe and effective. Oral TXA, being more economical and non-invasive compared to intravenous injection, holds promise for clinical use.
Competing Interests: Declaration of Competing Interest The authors declare no conflict of interest.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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