GOOD CORRELATION BETWEEN LIVER STIFFNESS MEASUREMENT AND APRI, FIB-4, PLATELET COUNT, IN PEDIATRIC AUTOIMMUNE HEPATITIS.

Autor: Alvarenga LR; Faculdade de Ciências Médicas da Universidade Estadual de Campinas, Departamento de Pediatria, Campinas, SP, Brasil., Sandy NS; Hospital Infantil Sabará, Programa Avançado de Tratamento da Insuficiência Intestinal (PATII), São Paulo, SP, Brasil.; Hospital Israelita Albert Einstein, Departamento de Pediatria, São Paulo, SP, Brasil., Hessel G; Faculdade de Ciências Médicas da Universidade Estadual de Campinas, Departamento de Pediatria, Campinas, SP, Brasil., Pereira TS; Faculdade de Ciências Médicas da Universidade Estadual de Campinas, Departamento de Gastroenterologia, Campinas, SP, Brasil., Bellomo-Brandão MÂ; Faculdade de Ciências Médicas da Universidade Estadual de Campinas, Departamento de Pediatria, Campinas, SP, Brasil.
Jazyk: angličtina
Zdroj: Arquivos de gastroenterologia [Arq Gastroenterol] 2024 Oct 21; Vol. 61, pp. e24047. Date of Electronic Publication: 2024 Oct 21 (Print Publication: 2024).
DOI: 10.1590/S0004-2803.24612024-047
Abstrakt: Background: There is limited evidence focusing on the use of non-invasive markers to assess liver fibrosis in pediatric chronic liver diseases.
Objective: The aim of the study was to evaluate the correlation between liver stiffness measurement (LSM) using transient liver elastography (TLE) and serum non-invasive markers in pediatric autoimmune hepatitis (AIH).
Methods: Cross-sectional study between May 2016 and February 2020. Twenty-eight children with AIH (age range between 3 and 20 years old) who had undergone TLE and had routine serum tests were enrolled. Patients were divided into 2 groups: (1) Liver fibrosis degree ≥F2 (TLE ≥6.45 kPa) and (2) Results: Twenty-eight AIH pediatric patients were enrolled, 21 were female and 22 had AIH type 1. Following the cut-off of 6.45 kPa in TLE, 20 patients (71%) were included in group 1, and 8 in group 2. A statistically significant difference was found between the two groups on APRI and FIB-4 results (P=0.0306 and P=0.0055, respectively). There was a significant correlation between TLE with APRI and FIB-4 (Rs=0.67 and 0.78, respectively; P<0.01) as well as with platelet count (Rs=-0.68; P<0.01).
Conclusion: APRI, FIB-4 and Platelet Count showed a good and positive correlation with transient liver elastography in pediatric patients with AIH.
Databáze: MEDLINE
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