Mediterranean Diet and Risk of Hip Fracture: A Systematic Review and Dose-Response Meta-Analysis.

Autor:	Fa-Binefa M; Universitat Autònoma de Barcelona, Barcelona 08041, Spain.; Hospital de la Santa Creu i Sant Pau, Barcelona 08041, Spain.; Sant Pau Biomedical Research Institute (IIB Sant Pau), Barcelona 08041, Spain., Clara A; Angiology and Vascular Surgery Department, Hospital del Mar, Barcelona 08009, España.; Hospital del Mar Research Institute, Barcelona 08009, Spain.; Centro de Investigación en Red de Enfermedades Cardiovasculares, Barcelona 08009, España., Lamas C; Universitat Autònoma de Barcelona, Barcelona 08041, Spain.; Hospital de la Santa Creu i Sant Pau, Barcelona 08041, Spain.; Sant Pau Biomedical Research Institute (IIB Sant Pau), Barcelona 08041, Spain., Elosua R; Hospital del Mar Research Institute, Barcelona 08009, Spain.; Centro de Investigación en Red de Enfermedades Cardiovasculares, Barcelona 08009, España.; Facultat de Medicina, Universitat de Vic-Universitat Central de Catalunya, Vic 08500, Spain.
Jazyk:	angličtina
Zdroj:	Nutrition reviews [Nutr Rev] 2024 Oct 23. Date of Electronic Publication: 2024 Oct 23.
DOI:	10.1093/nutrit/nuae141
Abstrakt:	Context: Hip fractures are a major public health concern. Understanding their epidemiologic and biological links with diet and cardiovascular risk may have important implications for prevention. Objective: To assess the dose-response association of Mediterranean diet (MD) adherence with the risk of hip fracture. Data Sources: A systematic search was conducted in the PubMed, Scopus, and Web of Science databases for prospective studies. Search terms were "Mediterranean Diet" and "Fracture." Data Extraction: Data were extracted from 8 studies, encompassing 15 cohorts that included 503 174 individuals. Methodological quality was assessed using the Risk of Bias in Nonrandomized Studies of Interventions. Data Analysis: The "meta" and "dosresmeta" packages were used in R Studio Software. The results demonstrated that high and moderate MD adherence were associated with a reduced risk of hip fracture (relative risk [RR] = 0.71 [95% CI, 0.55-0.91]; and RR = 0.78[(95% CI, 0.65-0.93], respectively). The effect of the association was similar in men and women. The dose-response pattern of the association was linear: each point increase in MD adherence was associated with a 5.25% reduction in hip fracture risk. Conclusions: Adherence to MD is associated with a reduction in hip fracture risk, following a linear dose-response pattern. This supports the promotion of this dietary pattern for improving bone health. Systematic Review Registration: PROSPERO registration no. CRD42023402284. (© The Author(s) 2024. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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