Encapsulation of the PHMB with nanoliposome and attachment to wound dressing for long-term antibacterial activity and biocompatibility.

Autor: Ahani E; Azad University, Science and Research Unit, Tehran, Iran., Montazer M; Functional Fibrous Structures & Environmental Enhancement (FFSEE), Department of Textile Engineering, Amirkabir University of Technology, Tehran, Iran. tex5mm@aut.ac.ir.; Textile Department, Amirkabir University of Technology, 424 Hafez Ave, Tehran, 15875-4413, Iran. tex5mm@aut.ac.ir., Mianehro A; Textile Department, Amirkabir University of Technology, 424 Hafez Ave, Tehran, 15875-4413, Iran., Samadi N; Department of Drug and Food Control, Faculty of Pharmacy and Biotechnology Research Center, Tehran University of Medical Sciences, Tehran, Iran., Toliyat T; Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran., Rad MM; Phytochemistry Research Center, Shahid Beheshti Medical Sciences, Tehran, Iran.
Jazyk: angličtina
Zdroj: World journal of microbiology & biotechnology [World J Microbiol Biotechnol] 2024 Oct 23; Vol. 40 (11), pp. 361. Date of Electronic Publication: 2024 Oct 23.
DOI: 10.1007/s11274-024-04170-0
Abstrakt: Concentration control of some drug are used commonly however their uncontrolled concentration renders severe side effects. Therefore, it is substantial to come up with innovation release control methods. There is a strong affinity between the phospholipid of nanoliposomes and wool cells which facilitate the diffusion of liposomes into the wool structure. On the other hand, polyhexamethylene biguanide (PHMB) has gained popularity as an antibacterial agent; however, the compound's cytotoxicity has limited its usefulness. By compounding these facts, this work introduces a novel method for sustained drug release via internalization. In this method, PHMB was detained into nanoliposomes infiltrated the wool to generate an extremely regulated release, which was established using various techniques. SEM pictures demonstrated effective absorption of nanoliposome-encapsulated PHMB within the wool fabric. The developed wound dressing showed a sustained drug release, and consequently, perfect biocompatibility and enduring antibacterial activity.
(© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
Databáze: MEDLINE
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