ANALYSIS OF THE CLINICAL EFFECTIVENESS OF USING THE CREATED COMBINED FIBRIN-BONE SCAFFOLD FOR THE RECONSTRUCTION OF BONE TISSUE DEFECTS OF THE JAWS.

Autor:	Yevchuk Y; Ivano-Frankivsk National Medical University, Ukraine., Rozhko M; Ivano-Frankivsk National Medical University, Ukraine., Pantus A; Ivano-Frankivsk National Medical University, Ukraine., Yarmoshuk I; Ivano-Frankivsk National Medical University, Ukraine., Pantus P; Ivano-Frankivsk National Medical University, Ukraine.
Jazyk:	angličtina
Zdroj:	Georgian medical news [Georgian Med News] 2024 Jul-Aug (352-353), pp. 6-13.
Abstrakt:	The aim of the study was the clinical study of the framework ability of the PRF scaffold obtained by simultaneous centrifugation of the patient's blood and bone-plastic material. Materials and Methods: A total of 60 patients, aged between 20 and 50 years, with radicular cysts of the jaws, were selected for inclusion into the clinical studies. All patients were divided into groups I and II, who underwent cystectomy and bone plastic surgery according to the standard technique using mineralized CenoBone®. However, group II used a scaffold prepared according to the protocol developed by us (patent №136410 and patent №156181) using a titanium Ti-6Al-4V filter developed by us (patent № 152966). Results: The results of the aforementioned postoperative radiological examinations confirm the efficacy of the filter, and the technique devised by our research team, which enables the creation of a stable fibrin matrix with embedded granules of bone-plastic material. The efficacy of the treatment was evidenced by the simultaneous uniform regeneration of bone tissue across the entire thickness of the defect in group II, with a success rate of 86.66%. This is evidenced by the organized architecture of bone tissue with a pronounced trabecular pattern, which correlated with bone density indices from 715.18+14.33 to 652.42+27.34 HU. In this group of patients, these values corresponded to the intact bone. In contrast, in 22 (77.08%) patients of group I, the predominant bone structure was compact, with values ranging from 965.47+21.25 to 876.26+24.67 HU. This observation is believed to be attributed to the presence of unresorbed material granules, which form a compact framework for bone germination. Nevertheless, among the 22 patients in group I, only 13 (59.09%) exhibited complete restoration of the defect, while the remaining 9 (40.91%) displayed indications of merely peripheral bone restoration, characterized by a pronounced granular pattern in the centre. Conclusions: The stable combined fibrin scaffold obtained by us, has a pronounced osteoconductive and osteoinductive effect, which is reflected in the complete restoration of bone tissue throughout the thickness of the defect.
Databáze:	MEDLINE
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