Granulomatous secondary syphilis - 2 case reports and review of the literature.
| Autor: | Lim DZJ; National Skin Centre, Singapore., Lim JH; National Skin Centre, Singapore., Wang DY; National Skin Centre, Singapore., Chio TM; National Skin Centre, Singapore.; Saw Swee Hock School of Public Health, National University Singapore, Singapore. |
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| Jazyk: | angličtina |
| Zdroj: | Clinical and experimental dermatology [Clin Exp Dermatol] 2024 Oct 23. Date of Electronic Publication: 2024 Oct 23. |
| DOI: | 10.1093/ced/llae448 |
| Abstrakt: | Granulomatous inflammation is usually described in association with tertiary syphilis up till recent years where there are emerging cases reporting its presence in secondary syphilis. Herein we present two patients who presented with erythematous infiltrated papules and nodules and were eventually diagnosed with granulomatous secondary syphilis, with clearance of their rashes after treatment. In this article, we highlight the important clues that point clinicians and histopathologists towards the diagnosis of syphilis compared to other similar differentials such as leprosy in reaction, cutaneous histiocytosis and lymphoma. Additionally, from literature review and own experiences, we wish to highlight that granulomatous syphilis is often palmoplantar sparing and its presence may not necessarily be a feature of immunocompromised states (e.g. human immunodeficiency virus) In this increasingly connected world, the recognition of an atypical presentation of an age-old disease in patients with different skin types needs to be underscored with close clinicopathological correlation. (© The Author(s) 2024. Published by Oxford University Press on behalf of British Association of Dermatologists. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.) |
| Databáze: | MEDLINE |
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