Subject-based assessment of large-scale integration dynamics in epileptic brain networks: insights from the intrinsic ignition framework.

Autor:	Donaire A; Epilepsy Program, Department of Neurology, Hospital Clínic, Neuroscience Institute, Carrer de Villarroel, 170, Barcelona, Catalonia, CP 08036, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Clinical and Experimental Neuroscience, Clinical Neurophysiology, Barcelona, Catalonia, CP 08036, Spain.; Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), University of Barcelona, Carrer de Casanova, 143, Barcelona, Catalonia, CP 08036, Spain., Padilla N; Department of Women's and Children's Health, Karolinska Institutet, Tomtebodavägen 18b, Stockholm, SE-171 77, Stockholm County, Sweden., Escrichs A; Computational Neuroscience Group Center for Brain and Cognition, Universitat Pompeu Fabra, C/ de Ramon Trias Fargas, 25, Barcelona, Catalonia, CP 08018, Spain., Khawja M; Epilepsy Program, Department of Neurology, Hospital Clínic, Neuroscience Institute, Carrer de Villarroel, 170, Barcelona, Catalonia, CP 08036, Spain., Setoain X; Epilepsy Program, Department of Neurology, Hospital Clínic, Neuroscience Institute, Carrer de Villarroel, 170, Barcelona, Catalonia, CP 08036, Spain.; Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), University of Barcelona, Carrer de Casanova, 143, Barcelona, Catalonia, CP 08036, Spain., Rumia J; Epilepsy Program, Department of Neurology, Hospital Clínic, Neuroscience Institute, Carrer de Villarroel, 170, Barcelona, Catalonia, CP 08036, Spain., Roldan P; Epilepsy Program, Department of Neurology, Hospital Clínic, Neuroscience Institute, Carrer de Villarroel, 170, Barcelona, Catalonia, CP 08036, Spain., Bargallo N; Epilepsy Program, Department of Neurology, Hospital Clínic, Neuroscience Institute, Carrer de Villarroel, 170, Barcelona, Catalonia, CP 08036, Spain., Boget T; Epilepsy Program, Department of Neurology, Hospital Clínic, Neuroscience Institute, Carrer de Villarroel, 170, Barcelona, Catalonia, CP 08036, Spain., Pintor L; Epilepsy Program, Department of Neurology, Hospital Clínic, Neuroscience Institute, Carrer de Villarroel, 170, Barcelona, Catalonia, CP 08036, Spain., Centeno M; Epilepsy Program, Department of Neurology, Hospital Clínic, Neuroscience Institute, Carrer de Villarroel, 170, Barcelona, Catalonia, CP 08036, Spain., Conde E; Epilepsy Program, Department of Neurology, Hospital Clínic, Neuroscience Institute, Carrer de Villarroel, 170, Barcelona, Catalonia, CP 08036, Spain., Vernet O; Epilepsy Program, Department of Neurology, Hospital Clínic, Neuroscience Institute, Carrer de Villarroel, 170, Barcelona, Catalonia, CP 08036, Spain., Buendía J; Epilepsy Program, Department of Neurology, Hospital Clínic, Neuroscience Institute, Carrer de Villarroel, 170, Barcelona, Catalonia, CP 08036, Spain., Manzanares I; Epilepsy Program, Department of Neurology, Hospital Clínic, Neuroscience Institute, Carrer de Villarroel, 170, Barcelona, Catalonia, CP 08036, Spain., Ådén U; Department of Women's and Children's Health, Karolinska Institutet, Tomtebodavägen 18b, Stockholm, SE-171 77, Stockholm County, Sweden.; Department of Neonatology, Karolinska University Hospital, Norrbacka, S3:03 Karolinska vägen 8, 171 76 Stockholm, Stockholm County, Sweden., Carreño M; Epilepsy Program, Department of Neurology, Hospital Clínic, Neuroscience Institute, Carrer de Villarroel, 170, Barcelona, Catalonia, CP 08036, Spain., Kringelbach M; Department of Psychiatry, University of Oxford, Warneford Hospital, Warneford Ln, Oxford, Oxfordshire, OX3 7JX, United Kingdom.; Center for Music in the Brain, Aarhus University Hospital, Nørrebrogade 44, Building 10G, 4th and 5th floor, Aarhus C, Central Denmark Region, 8000, Denmark., Deco G; Computational Neuroscience Group, Center for Brain and Cognition, Department of Information and Communication Technologies, Universitat Pompeu Fabra, C/ de Ramon Trias Fargas, 25, Barcelona, CP 08018, Spain.; School of Psychological Sciences, Monash University, Melbourne, Clayton, Victoria (VIC) 3800, Australia.; Institució Catalana de la Recerca i Estudis Avançats (ICREA), Passeig de Lluís Companys, 23, Barcelona, Catalonia, CP 08010, Spain.; Department of Neuropsychology, Max Planck Institute for human Cognitive and Brain Sciences, Leipzig, Saxony, 04103, Germany.
Jazyk:	angličtina
Zdroj:	Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2024 Oct 03; Vol. 34 (10).
DOI:	10.1093/cercor/bhae419
Abstrakt:	This study examined the dynamic properties of brain regions involved in the genesis and spread of seizures in 10 individuals diagnosed with pharmacoresistant focal epilepsy. The patients and 30 healthy controls underwent resting-state functional magnetic resonance imaging scans and the brain's functional network dynamics were analyzed using the intrinsic ignition framework. Comparative statistical analyses examined the differences in the integration and metastability measures in both groups in the whole brain and specific local brain regions. Invasive electroencephalography evaluations validated the findings of significant global and regional changes in the patient's brain network dynamics. There was a marked increase in global integration and metastability across the brain, reflecting substantial alterations in the overall connectivity and flexibility of the functional networks. Specific brain regions exhibited paradoxical dynamics within the seizure onset zone, with decreased intrinsic ignition and increased metastability. Increased intrinsic ignition was observed in remote brain regions, suggesting a reorganization of the brain network hubs and potential pathways for seizure propagation. Using the intrinsic ignition framework provided insights into dynamic alterations in the brain networks of patients with epilepsy. These have increased our understanding of the mechanisms underlying epileptic seizures and may guide the development of diagnostic biomarkers and targeted therapeutic interventions. (© The Author(s) 2024. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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